PMID- 20460950
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20100714
IS  - 1423-0372 (Electronic)
IS  - 1011-6125 (Linking)
VI  - 88
IP  - 4
DP  - 2010
TI  - Using Monte-Carlo-simulated radiation transport to calculate dose distribution in 
      rats before irradiation with Leksell Gamma Knife 4C: technical note.
PG  - 208-15
LID - 10.1159/000314355 [doi]
AB  - BACKGROUND: Gamma knife surgery (GKS) is used at subnecrotic doses for temporal 
      lobe epilepsy (TLE) treatment. Rat models of TLE have been used to probe the 
      mechanisms underlying GKS. Previous GKS studies on rats have used the Leksell 
      GammaPlan (LGP) treatment planning system to determine the irradiation time to 
      achieve the dose to deliver. Since LGP is not designed for such small structures, 
      it is important to calibrate the system for the rat brain. METHODS: We have used 
      a Monte Carlo simulation (MCS) radiation transport scheme, with CT data as 
      anatomical and tissue-specific information, to simulate the dose distribution in 
      a rat brain when using a Leksell Gamma Knife. RESULTS: We show how dose 
      distributions obtained by MCS quantitatively compare to those predicted by LGP, 
      and discuss whether LGP should be used for studies involving rats. The energy 
      deposited when using the 4-mm collimators was calculated for targets on both 
      sides of the rat brain in the dorsal hippocampus, which allowed us to determine 
      the exact time to irradiate rats with a given dose. CONCLUSION: The MCS method 
      used in this study can easily be used for future GKS studies on small animals 
      when accurate dose distributions are required.
CI  - 2010 S. Karger AG, Basel.
FAU - Marcelin, Beatrice
AU  - Marcelin B
AD  - INSERM U751, Universite de la Mediterranee, Hopital La Timone, Marseille, France.
FAU - Kjall, Per
AU  - Kjall P
FAU - Johansson, Jonas
AU  - Johansson J
FAU - Lundin, Anders
AU  - Lundin A
FAU - Nordstrom, Hakan
AU  - Nordstrom H
FAU - Eriksson, Markus
AU  - Eriksson M
FAU - Bernard, Christophe
AU  - Bernard C
FAU - Regis, Jean
AU  - Regis J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100512
PL  - Switzerland
TA  - Stereotact Funct Neurosurg
JT  - Stereotactic and functional neurosurgery
JID - 8902881
SB  - IM
MH  - Animals
MH  - Calibration
MH  - *Radiation Dosage
MH  - Radiosurgery/*instrumentation/methods
MH  - Radiotherapy Planning, Computer-Assisted/instrumentation/*methods
MH  - Rats
EDAT- 2010/05/13 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/05/13 06:00
PHST- 2009/07/31 00:00 [received]
PHST- 2010/03/04 00:00 [accepted]
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - 000314355 [pii]
AID - 10.1159/000314355 [doi]
PST - ppublish
SO  - Stereotact Funct Neurosurg. 2010;88(4):208-15. doi: 10.1159/000314355. Epub 2010 
      May 12.