PMID- 20462039
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20221207
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Feb
TI  - [Association of chinese medicine constitution and human leukocyte antigen-DQA1 
      gene polymorphism with outcomes of hepatitis B virus infection].
PG  - 141-5
AB  - OBJECTIVE: To observe the Chinese medicine constitution types and human leukocyte 
      antigen (HLA)-DQA1 gene polymorphism in patients with hepatitis B (HB) virus 
      infection in Chinese Han population of Zhejiang Province, for exploring the roles 
      of constitution factor in pathogenesis of HB. METHODS: A total of 240 subjects, 
      including 120 biopsy-proven chronic HB (CHB), 60 HB asymptomatic carrier (ASC) 
      and 60 resolved from HBV infection spontaneously (RHBS) were studied. Their 
      Chinese medicine constitution type was judged by Wangqi's classification, and 
      their genotype of HLA-DQA1 was detected by polymerase chain reaction sequence 
      specific primer for comparing the difference between groups in distribution 
      frequency (DF) of constitution types and genes. RESULTS: (1) As compared with the 
      RHBS group, DF of yin-deficiency constitution and phlegm-dampness constitution in 
      the CHB group was significant higher (20.0% vs. 6.7% and 12.5% vs. 1.7%), and 
      that of placid constitution was significant lower (11.7% vs. 31.7%), showing 
      statistical significance between groups (OR = 3.5, 95% CI: 1.16-10.60; OR = 8.4, 
      95% CI: 1.09-65.42; OR = 0.161, 95% CI: 0.076-0.34; all P < 0.05). (2) As 
      compared with the ASC group, DF of damp-heat constitution was significant higher 
      (24.2% vs. 6.7%, P < 0.05, OR = 4.462, 95% CI: 1.49-13.36), and that of placid 
      constitution was significant lower (11.7% vs. 45.0%, P < 0.01, OR = 0.285, 95% 
      CI: 0.13-0.62) in the CHB group. (3) As compared with RHBS group, DF of HLA-DQA1 
      * 0201 allele in CHB group was significant higher (38.3% vs. 5.8%, P < 0.01, OR = 
      10.04, 95% CI: 4.48-22.48); and that of HLA-DQA1 * 0102 allele was significant 
      lower (9.6% vs. 36.7%, P < 0.01, OR = 0.183, 95% CI: 0.10-0.32). (4) As compared 
      with ASC group, DF of HLA-DQA1 * 0201 allele in CHB group was significant higher 
      (38.3% vs. 7.5%, P < 0.01, OR = 7.667, 95% CI: 3.7-15.87), and that of HLA-DQA1 * 
      0102 allele was significant lower (20.0% vs. 9.6%, P < 0.01, OR = 0.424, 95% CI: 
      0.23-0.79). CONCLUSION: Both Chinese medicine constitution and HLA-DQA1 gene 
      polymorphism show connection with the outcomes of HB virus infection in Chinese 
      Han population, but the real association between them is required for further 
      study.
FAU - Xun, Yun-hao
AU  - Xun YH
AD  - The Sixth People's Hospital of Hangzhou.
FAU - Shi, Jun-ping
AU  - Shi JP
FAU - Guo, Jian-chun
AU  - Guo JC
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Body Constitution
MH  - Carrier State/virology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DQ alpha-Chains/*genetics
MH  - Hepatitis B/*diagnosis/*genetics/virology
MH  - Hepatitis B virus
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Young Adult
EDAT- 2010/05/14 06:00
MHDA- 2013/01/08 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Feb;30(2):141-5.