PMID- 20463743
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20111117
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 11
IP  - 5
DP  - 2010 Jul
TI  - Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for 
      multiple sclerosis in diverse Arab populations in Israel.
PG  - 423-31
LID - 10.1038/gene.2010.20 [doi]
AB  - Different multiple sclerosis (MS) prevalence rates were reported for Muslim and 
      Christian Arabs in Israel. In this study, we evaluated whether associations of 
      human leukocyte antigen (HLA) genes with MS may contribute to this prevalence 
      difference. DNA samples from Israeli Arab MS patients (n=109) and controls 
      (n=132) were typed for HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and -DQB1) 
      genes. Global comparisons of HLA allele frequencies revealed significant 
      differences between Christians and Muslims; therefore, case-control analyses were 
      stratified by religious affiliation. Disease characteristics of Muslim and 
      Christian Arab MS patients were similar to those reported for European 
      populations. Opposing association signals with MS were observed for alleles 
      composing the DRB1*0301-DQB1*0201 haplotype: positive association of the 
      HLA-DRB1*0301 allele in Muslims (P(Bonferroni)=0.004, odds ratio (OR)=3.07), and 
      negative association in Christian Arabs (P(Bonferroni)=0.01, OR=0.12), with 
      similar results obtained for HLA-DQB1*0201. HLA-B*52 was negatively associated 
      with MS only in Muslims (P(Bonferroni)=0.01, OR=0.03). The study presents for the 
      first time a high-resolution HLA gene analysis in clinically well-characterized 
      Arab populations with MS, and shows the population-specific contribution of the 
      DRB1*0301-DQB1*0201 haplotype to disease susceptibility.
FAU - Benedek, G
AU  - Benedek G
AD  - The Lautenberg Center for Immunology, Hebrew University Hadassah Medical School, 
      Jerusalem, Israel.
FAU - Paperna, T
AU  - Paperna T
FAU - Avidan, N
AU  - Avidan N
FAU - Lejbkowicz, I
AU  - Lejbkowicz I
FAU - Oksenberg, J R
AU  - Oksenberg JR
FAU - Wang, J
AU  - Wang J
FAU - Brautbar, C
AU  - Brautbar C
FAU - Israel, S
AU  - Israel S
FAU - Miller, A
AU  - Miller A
CN  - Israeli MS Genetics group
LA  - eng
GR  - AI067152/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100513
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arabs/ethnology/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*ethnology/genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Humans
MH  - Islam
MH  - Israel/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*ethnology/*genetics
MH  - Odds Ratio
MH  - Prevalence
FIR - Kahana, Ester
IR  - Kahana E
FIR - Karussis, Dimitrios
IR  - Karussis D
FIR - Masalha, Rafik
IR  - Masalha R
FIR - Miller, Ariel
IR  - Miller A
FIR - Petrou, Panayiota
IR  - Petrou P
FIR - Rawasdeh, Hana
IR  - Rawasdeh H
FIR - Shahein, Radi
IR  - Shahein R
EDAT- 2010/05/14 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - gene201020 [pii]
AID - 10.1038/gene.2010.20 [doi]
PST - ppublish
SO  - Genes Immun. 2010 Jul;11(5):423-31. doi: 10.1038/gene.2010.20. Epub 2010 May 13.