PMID- 20465355
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20151119
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Linking)
VI  - 42
IP  - 5
DP  - 2010 Jul
TI  - Co-occurrence of allergic sensitization and type 1 diabetes.
PG  - 352-9
LID - 10.3109/07853890.2010.481678 [doi]
AB  - BACKGROUND: The mechanisms leading to abnormal immune regulation in type 1 
      diabetes and allergic diseases may be partly overlapping. If so, these diseases 
      should co-occur more often than expected. We investigated this phenomenon in two 
      contrasting socio-economic environments, Finland and Russian Karelia. METHODS: We 
      screened 413 Finnish children (of whom 147 had type 1 diabetes) and 244 Russian 
      Karelian children (132 had type 1 diabetes) for total immunoglobulin E (IgE) 
      levels and specific IgE against birch, cat, and egg albumen. In addition we 
      analysed diabetes-related human leukocyte antigen (HLA) haplotypes and antibodies 
      against hepatitis A virus (HAV) and recorded allergic diseases by a questionnaire 
      in Russian Karelia. RESULTS: In Russian Karelia 15% of the patients with type 1 
      diabetes, but only 4% of the control subjects had allergen-specific IgE (P = 
      0.012). A similar difference was observed in the frequency of allergic symptoms. 
      Co-occurrence of allergic sensitization and type 1 diabetes was associated with 
      lack of HAV antibodies and was not seen in Finland where infections are less 
      frequent than in Karelia. CONCLUSION: Our findings support the idea of common 
      mechanisms in the pathogenesis of allergic diseases and type 1 diabetes, which 
      may be particularly important in an environment with low penetrance of these 
      diseases.
FAU - Seiskari, Tapio
AU  - Seiskari T
AD  - Department of Virology, University of Tampere, Tampere, Finland. 
      tapio.seiskari@uta.fi
FAU - Viskari, Hanna
AU  - Viskari H
FAU - Kondrashova, Anita
AU  - Kondrashova A
FAU - Haapala, Anna-Maija
AU  - Haapala AM
FAU - Ilonen, Jorma
AU  - Ilonen J
FAU - Knip, Mikael
AU  - Knip M
FAU - Hyoty, Heikki
AU  - Hyoty H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (HLA Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/*complications/epidemiology/ethnology
MH  - Female
MH  - Finland/epidemiology
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Hypersensitivity/*complications/epidemiology/ethnology
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Russia/epidemiology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/05/15 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.3109/07853890.2010.481678 [doi]
PST - ppublish
SO  - Ann Med. 2010 Jul;42(5):352-9. doi: 10.3109/07853890.2010.481678.