PMID- 20466795
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20211020
IS  - 1521-0103 (Electronic)
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 334
IP  - 2
DP  - 2010 Aug
TI  - Endocrine and neurochemical effects of 3,4-methylenedioxymethamphetamine and its 
      stereoisomers in rhesus monkeys.
PG  - 642-50
LID - 10.1124/jpet.110.166595 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that 
      elicits complex biological effects in humans. One plausible mechanism for this 
      phenomenon is that racemic MDMA is composed of two stereoisomers that exhibit 
      qualitatively different pharmacological effects. In support of this, studies have 
      shown that R(-)-MDMA tends to have hallucinogen-like effects, whereas S(+)-MDMA 
      tends to have psychomotor stimulant-like effects. However, relatively little is 
      known about whether these stereoisomers engender different endocrine and 
      neurochemical effects. In the present study, the endocrine and neurochemical 
      effects of each stereoisomer and the racemate were assessed in four rhesus 
      monkeys after intravenous delivery at doses (1-3 mg/kg) that approximated 
      voluntary self-administration by rhesus monkeys and human recreational users. 
      Specifically, fluorescence-based enzyme-linked immunosorbent assay was used to 
      assess plasma prolactin concentrations, and in vivo microdialysis was used to 
      assess extracellular dopamine and serotonin concentrations in the dorsal 
      striatum. R(-)-MDMA, but not S(+)-MDMA, significantly increased plasma prolactin 
      levels and the effects of S,R(+/-)-MDMA were intermediate to each of its 
      component stereoisomers. Although S(+)-MDMA did not alter prolactin levels, it 
      did significantly increase extracellular serotonin concentrations. In addition, 
      S(+)-MDMA, but not R(-)-MDMA, significantly increased dopamine concentrations. 
      Furthermore, as in the prolactin experiment, the effects of the racemate were 
      intermediate to each of the stereoisomers. These studies demonstrate the 
      stereoisomers of MDMA engender qualitatively different endocrine and 
      neurochemical effects, strengthening the inference that differences in these 
      stereoisomers might be the mechanism producing the complex biological effects of 
      the racemic mixture of MDMA in humans.
FAU - Murnane, K S
AU  - Murnane KS
AD  - Division of Neuroscience, Yerkes National Primate Research Center, Atlanta, 
      Georgia 30322, USA.
FAU - Fantegrossi, W E
AU  - Fantegrossi WE
FAU - Godfrey, J R
AU  - Godfrey JR
FAU - Banks, M L
AU  - Banks ML
FAU - Howell, L L
AU  - Howell LL
LA  - eng
GR  - K02 DA000517/DA/NIDA NIH HHS/United States
GR  - Z01 DA000517/ImNIH/Intramural NIH HHS/United States
GR  - RR020146/RR/NCRR NIH HHS/United States
GR  - DA10344/DA/NIDA NIH HHS/United States
GR  - P20 RR020146/RR/NCRR NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - T32 DA015040/DA/NIDA NIH HHS/United States
GR  - R21 DA020645/DA/NIDA NIH HHS/United States
GR  - RR00165/RR/NCRR NIH HHS/United States
GR  - R37 DA010344/DA/NIDA NIH HHS/United States
GR  - R01 DA010344/DA/NIDA NIH HHS/United States
GR  - DA020645/DA/NIDA NIH HHS/United States
GR  - DA15040/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100513
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 9002-62-4 (Prolactin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Central Nervous System Stimulants/chemistry/*pharmacology
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Dopamine/*metabolism
MH  - Extracellular Space/metabolism
MH  - Female
MH  - Hallucinogens/chemistry/*pharmacology
MH  - Homovanillic Acid/metabolism
MH  - Macaca mulatta
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/chemistry/*pharmacology
MH  - Prolactin/*metabolism
MH  - Serotonin/*metabolism
MH  - Stereoisomerism
MH  - Structure-Activity Relationship
PMC - PMC2913775
EDAT- 2010/05/15 06:00
MHDA- 2010/08/18 06:00
PMCR- 2011/08/01
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - jpet.110.166595 [pii]
AID - 3607557 [pii]
AID - 10.1124/jpet.110.166595 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2010 Aug;334(2):642-50. doi: 10.1124/jpet.110.166595. Epub 
      2010 May 13.