PMID- 20467224
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20151119
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 51
IP  - 4
DP  - 2010 Apr
TI  - [Serum free light-chain assay for nonsecretory multiple myeloma with light chain 
      cast nephropathy and light chain deposition disease].
PG  - 270-4
AB  - Quantitative assay for serum free light chains (sFLC) is reported as a useful 
      test for diagnosis and monitoring of patients with nonsecretory multiple myeloma 
      (NSM). We performed serial sFLC assays in a patient with NSM with light chain 
      cast nephropathy (LCCN) and light chain deposition disease (LCDD). After 3 cycles 
      of VAD induction therapy, while plasma cells in the marrow decreased from 93.0% 
      to 0.2%, sFLCkappa/lambda ratio remained abnormal. Flow cytometry assay also 
      showed that these plasma cells were CD19 negative. After the subsequent high dose 
      melphalan therapy followed by autologous peripheral blood stem cell 
      transplantation (PBSCT), the sFLCkappa/lambda ratio returned to normal and the 
      patient achieved a stringent complete response (sCR). One year after PBSCT, the 
      patient remained in sCR with improved renal function. The quantitative FLC assay 
      was useful for the diagnosis and monitoring of NSM and LCDD in this patient.
FAU - Honma, Riko
AU  - Honma R
AD  - Department of Medicine, Yamagata Prefectural Central Hospital.
FAU - Fukase, Sachiko
AU  - Fukase S
FAU - Suzuki, Masayuki
AU  - Suzuki M
FAU - Omoto, Eijiro
AU  - Omoto E
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin Light Chains)
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 5J49Q6B70F (Vincristine)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 80168379AG (Doxorubicin)
RN  - Q41OR9510P (Melphalan)
RN  - VAD protocol
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & 
      dosage/therapeutic use
MH  - Biomarkers/blood
MH  - Dexamethasone/administration & dosage
MH  - Doxorubicin/administration & dosage
MH  - Female
MH  - Humans
MH  - Immunoassay/methods
MH  - Immunoglobulin Light Chains/*blood/metabolism
MH  - Kidney Diseases/*complications/metabolism
MH  - Melphalan/administration & dosage
MH  - Middle Aged
MH  - Multiple Myeloma/*complications/*diagnosis/therapy
MH  - Peripheral Blood Stem Cell Transplantation
MH  - Reagent Kits, Diagnostic
MH  - Vincristine/administration & dosage
EDAT- 2010/05/15 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - JST.JSTAGE/rinketsu/51.270 [pii]
PST - ppublish
SO  - Rinsho Ketsueki. 2010 Apr;51(4):270-4.