PMID- 20467454
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9759 (Electronic)
IS  - 1687-9740 (Print)
IS  - 1687-9740 (Linking)
VI  - 2010
DP  - 2010
TI  - NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to 
      Caloric Deprivation.
PG  - 983468
LID - 10.1155/2010/983468 [doi]
LID - 983468
AB  - Background. Brain natriuretic peptide and its inactive fragment N-terminal 
      pro-BNP (N-BNP) are reliable markers of ventricular dysfunction in adults and 
      children. We analyzed the impact of nutritional state on N-BNP levels in infants 
      with failure to thrive (FTT) and in infants with severe heart failure (HF). The 
      purpose of this study was to compare N-BNP levels in infants with FTT with 
      infants with severe HF and healthy controls. Methods. In a retrospective cohort 
      study, we compared N-BNP levels from all consecutive infants with FTT and 
      bodyweight below the tenth percentile (caloric deprivation (CD) group) to infants 
      with severe HF. Reference values from infants between 2 and 12 month were taken 
      from the literature and healthy infants. Results. Our results show that infants 
      with FTT (n = 15) had significantly (P < .001) elevated N-BNP values compared 
      with the healthy infants (n = 23), 530 (119-3150) pg/mL versus 115 (15-1121) 
      pg/mL. N-BNP values in this CD group are comparable to the median value of 
      infants with severe HF (n = 12) 673 (408-11310) pg/mL. There is no statistical 
      significant difference in age. Conclusion. Nutritional state has an important 
      impact on N-BNP levels in infants with FTT. We could show comparable levels of 
      N-BNP in infants with FTT and infants with severe HF.
FAU - Manhardt, L B
AU  - Manhardt LB
AD  - Department of Paediatrics, Caritas Krankenhaus, Uhlandstrasse. 7, 97980 Bad 
      Mergentheim, Germany.
FAU - Norozi, K
AU  - Norozi K
FAU - Muller, C
AU  - Muller C
FAU - Willaschek, C
AU  - Willaschek C
FAU - Kostuch, B
AU  - Kostuch B
FAU - Buchhorn, R
AU  - Buchhorn R
LA  - eng
PT  - Journal Article
DEP - 20100504
PL  - Egypt
TA  - Int J Pediatr
JT  - International journal of pediatrics
JID - 101517077
PMC - PMC2864906
EDAT- 2010/05/15 06:00
MHDA- 2010/05/15 06:01
PMCR- 2010/05/04
CRDT- 2010/05/15 06:00
PHST- 2009/09/18 00:00 [received]
PHST- 2009/12/28 00:00 [revised]
PHST- 2010/02/25 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/05/15 06:01 [medline]
PHST- 2010/05/04 00:00 [pmc-release]
AID - 10.1155/2010/983468 [doi]
PST - ppublish
SO  - Int J Pediatr. 2010;2010:983468. doi: 10.1155/2010/983468. Epub 2010 May 4.