PMID- 20467777
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20161020
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Aug
TI  - Plasma adrenomedullin and proadrenomedullin N-terminal 20 peptide in patients 
      diagnosed as having early rheumatoid arthritis.
PG  - 389-95
LID - 10.1007/s10165-010-0295-5 [doi]
AB  - The aim of this study was to investigate plasma adrenomedullin (AM) and 
      proadrenomedullin N-terminal 20 peptide (PAMP) level in patients diagnosed with 
      early rheumatoid arthritis (RA). Furthermore, several inflammatory cytokines were 
      measured in those patients to clarify the roles of AM and PAMP. Forty patients 
      diagnosed with early RA (women 46 +/- 8.5 years old) and 10 healthy controls 
      (women 57 +/- 5 years old) were studied. Plasma levels of AM, PAMP, matrix 
      metalloprotease 3 (MMP-3), interleukin 6 (IL-6), tumor necrosis factor alpha 
      (TNF-alpha), and C-reactive protein (CRP) were measured using an 
      immunoradiometric assay and enzyme-linked immunosorbent asay (ELISA) methods. The 
      plasma levels of AM (17.5 +/- 8.4 fmol/ml) and PAMP (2.01 +/- 0.57 fmol/ml) in 
      patients exceeded those in healthy controls (AM 8.6 +/- 1.7, PAMP 1.17 +/- 0.34 
      fmol/ml). Moreover, plasma AM and PAMP levels demonstrated a significantly 
      positive correlation with plasma MMP-3 and IL-6 levels. Nevertheless, CRP and 
      TNF-alpha levels in these patients showed no significant correlation with plasma 
      AM and PAMP levels. These data support the possible role for AM and PAMP in the 
      pathophysiology of early RA.
FAU - Hamada, Hiroaki
AU  - Hamada H
AD  - Department of Orthopedic Surgery, Faculty of Medicine, University of Miyazaki, 
      Kiyotake, Miyazaki, Japan. hiroaki@fc.miyazaki-u.ac.jp
FAU - Saisyo, Koichiro
AU  - Saisyo K
FAU - Sekimoto, Tomohisa
AU  - Sekimoto T
FAU - Chosa, Etsuo
AU  - Chosa E
LA  - eng
PT  - Journal Article
DEP - 20100514
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (ADM protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 148498-78-6 (Adrenomedullin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adrenomedullin/*blood/*immunology
MH  - Adult
MH  - *Arthritis, Rheumatoid/blood/diagnosis/immunology
MH  - C-Reactive Protein/metabolism
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Matrix Metalloproteinase 3/blood
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2010/05/15 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/05/15 06:00
PHST- 2009/10/15 00:00 [received]
PHST- 2010/03/03 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.1007/s10165-010-0295-5 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2010 Aug;20(4):389-95. doi: 10.1007/s10165-010-0295-5. Epub 2010 
      May 14.