PMID- 20470761
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1346
DP  - 2010 Jul 30
TI  - Correlation of auditory event-related potentials and magnetic resonance 
      spectroscopy measures in mild cognitive impairment.
PG  - 204-12
LID - 10.1016/j.brainres.2010.04.078 [doi]
AB  - This study was aimed to examine the changes in auditory event-related potentials 
      (AERPs) and their relationship with brain metabolic changes in mild cognitive 
      impairment (MCI). 34 MCI patients and 34 healthy elderly controls were subjected 
      to auditory stimulus oddball task, and then post-stimulus potentials (P50, N100, 
      P200, N200, and P300) were obtained, levels of N-acetylaspartate (NAA), creatine 
      (Cr) and the ratio of NAA/Cr were measured by proton magnetic resonance 
      spectroscopy (1H-MRS) in left frontal, left temporal and right parietal cortex. 
      Compared with the control group, the MCI group had significantly increased P50 
      amplitudes and P300 latency, and the NAA/Cr was abnormal. Linear progression 
      analysis revealed a strong negative correlation between P50 amplitudes and NAA/Cr 
      in left frontal cortex, and negative correlation between P300 latency and NAA/Cr 
      in left frontal and left temporal, as well as correlation of AERP components and 
      MRS metabolites with clinical scores of cognitive tests. These findings suggest 
      that metabolic abnormalities of different brain regions may reflect the changes 
      of underlying brain activities that are instrumental in the MCI. Therefore AERPs 
      and MRS measurements may offer a mean to track changes of brain activities 
      associated with functional changes, and to assess early cognitive impairment in 
      MCI.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Li, Xiaoyi
AU  - Li X
AD  - Department of Neurology, Daping Hospital, Third Military Medical University, 
      Chongqing, China.
FAU - Shao, Xicang
AU  - Shao X
FAU - Wang, Nanzhu
AU  - Wang N
FAU - Wang, Tao
AU  - Wang T
FAU - Chen, Geyu
AU  - Chen G
FAU - Zhou, Huadong
AU  - Zhou H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100512
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 997-55-7 (N-acetylaspartate)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Acoustic Stimulation
MH  - Aged
MH  - Aspartic Acid/analogs & derivatives/metabolism
MH  - Brain Chemistry/*physiology
MH  - Cognition Disorders/*metabolism/*physiopathology/psychology
MH  - Creatine/metabolism
MH  - Electroencephalography
MH  - Electrooculography
MH  - Event-Related Potentials, P300/physiology
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Neuropsychological Tests
MH  - Prefrontal Cortex/metabolism/physiology
MH  - Psychomotor Performance/physiology
EDAT- 2010/05/18 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/01/28 00:00 [received]
PHST- 2010/04/28 00:00 [revised]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - S0006-8993(10)01014-0 [pii]
AID - 10.1016/j.brainres.2010.04.078 [doi]
PST - ppublish
SO  - Brain Res. 2010 Jul 30;1346:204-12. doi: 10.1016/j.brainres.2010.04.078. Epub 
      2010 May 12.