PMID- 20470770
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20200325
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 640
IP  - 1-3
DP  - 2010 Aug 25
TI  - Neuroprotective efficacy and therapeutic window of Forsythoside B: in a rat model 
      of cerebral ischemia and reperfusion injury.
PG  - 75-81
LID - 10.1016/j.ejphar.2010.04.055 [doi]
AB  - The present study was to investigate the neuroprotective efficacy and mechanism 
      of Forsythoside B. Male Sprague-Dawley rats were subjected to middle cerebral 
      artery occlusion for 1 h followed by reperfusion for 23 h. Rats received an 
      intravenous bolus injection of Forsythoside B at 15 min after reperfusion. The 
      results showed that Forsythoside B at doses higher than 8 mg/kg produced a 
      significant neuroprotective potential in cerebral ischemia and reperfusion rats. 
      Forsythoside B (20 mg/kg) demonstrated significant neuroprotective activity even 
      after delayed administration at 1 h, 3 h and 5 h after cerebral ischemia and 
      reperfusion. Forsythoside B 20 mg/kg attenuated histopathological damage as 
      demonstrated by smaller brain infarct size and brain edema, decreased cerebral 
      Evans blue extravasation and myeloperoxidase (MPO) activity, inhibited cerebral 
      phosphor-IkappaB-alpha and nuclear transcription factors kappaB (NF-kappaB) 
      expression. Meanwhile, NF-kappaB expression with immunohistochemical staining was 
      reduced, while circulating polymorphonuclear leukocytes was increased. All of 
      these findings suggested that Forsythoside B exerted potent neuroprotective 
      effects with a favorable therapeutic time-window, reduce of cerebral ischemia and 
      reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and 
      its protective effects may be due to inhibition of inflammatory response.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Jiang, Wang-Lin
AU  - Jiang WL
AD  - School of Pharmacy, Yantai University, 32# Qingquan Road, Laishan District, 
      Yantai 264003, PR China.
FAU - Tian, Jing-Wei
AU  - Tian JW
FAU - Fu, Feng-hua
AU  - Fu FH
FAU - Zhu, Hai-Bo
AU  - Zhu HB
FAU - Hou, Jian
AU  - Hou J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100512
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antigens, Nuclear)
RN  - 0 (Caffeic Acids)
RN  - 0 (Glucosides)
RN  - 0 (Glycosides)
RN  - 0 (NF-kappa B)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Rbfox3 protein, rat)
RN  - 0 (forsythoside B)
RN  - 45PG892GO1 (Evans Blue)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use/toxicity
MH  - Antigens, Nuclear/metabolism
MH  - Brain Infarction/complications/drug therapy/metabolism/pathology
MH  - Brain Ischemia/complications/*drug therapy/metabolism/pathology
MH  - Caffeic Acids/*pharmacology/therapeutic use/toxicity
MH  - Disease Models, Animal
MH  - Evans Blue/metabolism
MH  - Extravasation of Diagnostic and Therapeutic Materials
MH  - Glucosides/*pharmacology/therapeutic use/toxicity
MH  - Glycosides/*pharmacology/therapeutic use/toxicity
MH  - Leukocytes/drug effects
MH  - Male
MH  - NF-kappa B/metabolism
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurons/drug effects/immunology/metabolism
MH  - Neuroprotective Agents/*pharmacology/therapeutic use/toxicity
MH  - Peroxidase/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reperfusion Injury/complications/*drug therapy/metabolism/pathology
EDAT- 2010/05/18 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/05/18 06:00
PHST- 2009/12/13 00:00 [received]
PHST- 2010/03/31 00:00 [revised]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - S0014-2999(10)00387-0 [pii]
AID - 10.1016/j.ejphar.2010.04.055 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2010 Aug 25;640(1-3):75-81. doi: 10.1016/j.ejphar.2010.04.055. 
      Epub 2010 May 12.