PMID- 20471020
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20191210
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1217
IP  - 26
DP  - 2010 Jun 25
TI  - Qualitative drug analysis of hair extracts by comprehensive two-dimensional gas 
      chromatography/time-of-flight mass spectrometry.
PG  - 4402-10
LID - 10.1016/j.chroma.2010.04.020 [doi]
AB  - A technique using comprehensive two-dimensional gas chromatography/time-of-flight 
      mass spectrometry (GCxGC/TOFMS) is applied to a qualitative analysis of three 
      sample extracts from hair suspected of containing various drug compounds. The 
      samples were also subjected to a quantitative target analysis for codeine, 
      morphine, 6-monoacetylmorphine (6-MAM), amphetamine, methamphetamine, 
      methylenedioxyamphetamine (MDA), methylenedioxymethylamphetamine (MDMA), 
      methadone, and benzylpiperazine (BZP) by liquid chromatography-tandem mass 
      spectrometry (LC-MS/MS). GCxGC/TOFMS provided a non-specific procedure that 
      identified various drugs, metabolites, and impurities not included in the target 
      analysis. They included cocaine, diazepam, and methaqualone (quaalude). 
      Comprehensive GCxGC separation was achieved using twin-stage cryo-modulation to 
      focus eluant from a DB-5 ms (5% phenyl) to a BPX50 (50% phenyl) GC column. The 
      TOF mass spectrometer provided unit mass resolution in the mass range m/z 5-1000 
      and rapid spectral acquisition (< or = 500spectra/s). Clean mass spectra of the 
      individual components were obtained using mass spectral deconvolution software. 
      The 'unknown' components were identified by comparison with mass spectra stored 
      in a library database.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Guthery, Bill
AU  - Guthery B
AD  - Planetary and Space Sciences Research Institute, The Open University, Walton 
      Hall, Milton Keynes, MK7 6AA, UK. w.guthery@open.ac.uk
FAU - Bassindale, Tom
AU  - Bassindale T
FAU - Bassindale, Alan
AU  - Bassindale A
FAU - Pillinger, Colin T
AU  - Pillinger CT
FAU - Morgan, Geraint H
AU  - Morgan GH
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100424
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Hair/*chemistry
MH  - Humans
MH  - Pharmaceutical Preparations/*analysis
EDAT- 2010/05/18 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2010/03/19 00:00 [revised]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S0021-9673(10)00488-7 [pii]
AID - 10.1016/j.chroma.2010.04.020 [doi]
PST - ppublish
SO  - J Chromatogr A. 2010 Jun 25;1217(26):4402-10. doi: 10.1016/j.chroma.2010.04.020. 
      Epub 2010 Apr 24.