PMID- 20471835
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20220318
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Print)
IS  - 0967-5868 (Linking)
VI  - 17
IP  - 7
DP  - 2010 Jul
TI  - Relationship between brain interstitial fluid tumor necrosis factor-alpha and 
      cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
PG  - 853-6
LID - 10.1016/j.jocn.2009.11.041 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) has a crucial role in the onset of 
      hemolysis-induced vascular injury and cerebral vasoconstriction. We hypothesized 
      that TNF-alpha measured from brain interstitial fluid would correlate with the 
      severity of vasospasm following aneurysmal subarachnoid hemorrhage (aSAH). From a 
      consecutive series of 10 aSAH patients who underwent cerebral microdialysis (MD) 
      and evaluation of vasospasm by CT angiogram (CTA) or digital subtraction 
      angiography (DSA), TNF-alpha levels from MD were measured at 8-hour intervals 
      from aSAH days 4-6 using enzyme-linked immunosorbent assay. An attending 
      neuroradiologist blinded to the study independently evaluated each CTA and DSA 
      and assigned a vasospasm index (VI). Five patients had a VI<2 and 5 patients had 
      a VI>2, where the median VI was 2 (range 0-13). The median log TNF-alpha area 
      under the curve (AUC) was 1.64pg/mL *day (interquartile range 1.48-1.71) for the 
      VI<2 group, and 2.11pg/mL *day (interquartile range 1.95-2.47) for the VI>2 group 
      (p<0.01). Thus, in this small series of poor-grade aSAH patients, the AUC of 
      TNF-alpha levels from aSAH days 4-6 correlates with the severity of radiographic 
      vasospasm. Further analysis in a larger population is warranted based on our 
      preliminary findings.
FAU - Hanafy, Khalid A
AU  - Hanafy KA
AD  - Columbia University Medical Center, Division of Neurocritical Care, Columbia 
      University College of Physicians and Surgeons, Milstein Hospital Room 8GS-331, 
      New York, New York 10032, USA. kh2401@columbia.edu
FAU - Stuart, R Morgan
AU  - Stuart RM
FAU - Khandji, Alexander G
AU  - Khandji AG
FAU - Connolly, E Sander
AU  - Connolly ES
FAU - Badjatia, Neeraj
AU  - Badjatia N
FAU - Mayer, Stephan A
AU  - Mayer SA
FAU - Schindler, Christian
AU  - Schindler C
LA  - eng
GR  - R01 AI058211/AI/NIAID NIH HHS/United States
GR  - R01 AI058211-05/AI/NIAID NIH HHS/United States
GR  - R21 ES016835/ES/NIEHS NIH HHS/United States
GR  - R21 ES016835-01/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20100514
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/*blood supply/*metabolism/pathology
MH  - Extracellular Fluid/chemistry/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Microdialysis/methods
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Subarachnoid Hemorrhage/diagnosis/etiology/*metabolism
MH  - Tumor Necrosis Factor-alpha/analysis/*physiology
MH  - Vasospasm, Intracranial/diagnosis/etiology/*metabolism
PMC - PMC2878881
MID - NIHMS190997
EDAT- 2010/05/18 06:00
MHDA- 2010/12/14 06:00
PMCR- 2011/07/01
CRDT- 2010/05/18 06:00
PHST- 2009/11/04 00:00 [received]
PHST- 2009/11/24 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - S0967-5868(10)00208-0 [pii]
AID - 10.1016/j.jocn.2009.11.041 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2010 Jul;17(7):853-6. doi: 10.1016/j.jocn.2009.11.041. Epub 2010 
      May 14.