PMID- 20472063
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20211020
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 40
IP  - 1
DP  - 2010 Oct
TI  - The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of 
      dopaminergic neurons.
PG  - 102-12
LID - 10.1016/j.nbd.2010.05.008 [doi]
AB  - Dopamine is cytotoxic and may play a role in the development of Parkinson's 
      disease. However, its interaction with environmental risk factors such as 
      pesticides remains poorly understood. The vesicular monoamine transporter (VMAT) 
      regulates intracellular dopamine content, and we have tested the neuroprotective 
      effects of VMAT in vivo using the model organism Drosophila melanogaster. We find 
      that Drosophila VMAT (dVMAT) mutants contain fewer dopaminergic neurons than wild 
      type, consistent with a developmental effect, and that dopaminergic cell loss in 
      the mutant is exacerbated by the pesticides rotenone and paraquat. Overexpression 
      of DVMAT protein does not increase the survival of animals exposed to rotenone, 
      but blocks the loss of dopaminergic neurons caused by this pesticide. These 
      results are the first to demonstrate an interaction between a VMAT and pesticides 
      in vivo, and provide an important model to investigate the mechanisms by which 
      pesticides and cellular DA may interact to kill dopaminergic cells.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Lawal, Hakeem O
AU  - Lawal HO
AD  - Department of Psychiatry and Biobehavioral Sciences, Gonda Center for 
      Neuroscience and Genetics Research, David Geffen School of Medicine at University 
      of California, Los Angeles, California, USA.
FAU - Chang, Hui-Yun
AU  - Chang HY
FAU - Terrell, Ashley N
AU  - Terrell AN
FAU - Brooks, Elizabeth S
AU  - Brooks ES
FAU - Pulido, Dianne
AU  - Pulido D
FAU - Simon, Anne F
AU  - Simon AF
FAU - Krantz, David E
AU  - Krantz DE
LA  - eng
GR  - R01 ES015747/ES/NIEHS NIH HHS/United States
GR  - MH076900/MH/NIMH NIH HHS/United States
GR  - ES015747/ES/NIEHS NIH HHS/United States
GR  - R01 MH076900/MH/NIMH NIH HHS/United States
GR  - P01 ES016732/ES/NIEHS NIH HHS/United States
GR  - ES016732/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100526
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Growth Substances)
RN  - 0 (Pesticides)
RN  - 0 (Vesicular Monoamine Transport Proteins)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Cell Death/drug effects/physiology
MH  - Cell Survival/drug effects/physiology
MH  - Disease Models, Animal
MH  - Dopamine/*physiology
MH  - Down-Regulation/drug effects/physiology
MH  - Drosophila melanogaster/drug effects/*physiology
MH  - Growth Substances/genetics/physiology
MH  - Neural Inhibition/drug effects/physiology
MH  - Neurons/drug effects/*metabolism/pathology
MH  - Pesticides/*antagonists & inhibitors/*toxicity
MH  - Vesicular Monoamine Transport Proteins/*physiology
PMC - PMC2926123
MID - NIHMS216521
EDAT- 2010/05/18 06:00
MHDA- 2011/05/17 06:00
PMCR- 2011/10/01
CRDT- 2010/05/18 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/05/04 00:00 [revised]
PHST- 2010/05/06 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - S0969-9961(10)00159-2 [pii]
AID - 10.1016/j.nbd.2010.05.008 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2010 Oct;40(1):102-12. doi: 10.1016/j.nbd.2010.05.008. Epub 2010 
      May 26.