PMID- 20472348
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20161125
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 78
IP  - 3
DP  - 2010 Nov 1
TI  - Sparing of the neural stem cell compartment during whole-brain radiation therapy: 
      a dosimetric study using helical tomotherapy.
PG  - 946-54
LID - 10.1016/j.ijrobp.2009.12.012 [doi]
AB  - PURPOSE: To assess the feasibility of dosimetrically sparing the hippocampus and 
      neural stem cell (NSC) compartment during whole-brain radiotherapy (WBRT) and 
      prophylactic cranial irradiation (PCI). METHODS AND MATERIALS: We contoured the 
      brain/brainstem on fused magnetic resonance /computed tomography images as the 
      planning target volume (PTV) in 10 patients, excluding the hippocampus and NSC 
      compartment as organs at risk. PCI and WBRT helical tomotherapy plans were 
      prepared for each patient, with 1.0-cm field width, a pitch of 0.285, and a 
      modulation factor of 2.5. We attempted to maximally spare the hippocampus and NSC 
      compartment while treating the rest of the brain to 30 Gy in 15 fractions (PCI) 
      or 35 Gy in 14 fractions (WBRT) with a V(100) of >/=95%. Plan quality was assessed 
      by calculating mean dose, equivalent uniform dose (EUD), and biologically 
      equivalent dose (BED) for organs at risk and the percent volume of the PTV 
      receiving the prescribed dose of V(100). RESULTS: In the PCI plans, mean 
      doses/EUD/BED for the hippocampus and NSC compartment were 11.5 Gy/13.1 Gy/15.7 
      Gy(2) (BED assuming alpha/beta ratio of 2Gy) and 11.5 Gy/13.1 Gy/12.3 Gy(10) (BED 
      assuming alpha/beta ratio of 10Gy), respectively. In the WBRT plans, mean 
      doses/EUD/BED for the hippocampus and NSC compartment were 11.8 Gy/14.8 Gy/16.8 
      Gy(2) and 11.8 Gy/14.8 Gy/12.8 Gy(10), respectively. The mean V(95) for the rest 
      of the brain (PTV) was 96.9% for both the PCI and WBRT plans. Mean PCI and WBRT 
      treatment times were 15.93 min (range, 14.28 min-17.50 min) and 20.18 min (range, 
      18.43 min-22.32 min), respectively. CONCLUSIONS: It is dosimetrically feasible to 
      spare the hippocampus and NSC compartment using helical tomotherapy during the 
      administration of whole-brain irradiation.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Marsh, James C
AU  - Marsh JC
AD  - Department of Radiation Oncology, Rush University Medical Center, Chicago, 
      Illinois 60612, USA. james_marsh@rush.edu
FAU - Godbole, Rohit H
AU  - Godbole RH
FAU - Herskovic, Arnold M
AU  - Herskovic AM
FAU - Gielda, Benjamin T
AU  - Gielda BT
FAU - Turian, Julius V
AU  - Turian JV
LA  - eng
PT  - Journal Article
DEP - 20100514
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Brain/anatomy & histology/diagnostic imaging
MH  - Brain Neoplasms/prevention & control
MH  - Brain Stem/anatomy & histology/diagnostic imaging
MH  - Cranial Irradiation/adverse effects/*methods
MH  - Dentate Gyrus/cytology/radiation effects
MH  - Feasibility Studies
MH  - Hippocampus/anatomy & histology/cytology/diagnostic imaging/*radiation effects
MH  - Humans
MH  - Lateral Ventricles/anatomy & histology/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Pluripotent Stem Cells/cytology/*radiation effects
MH  - Radiation Injuries/*prevention & control
MH  - Radiotherapy Dosage
MH  - Relative Biological Effectiveness
MH  - Tomography, Spiral Computed/*methods
MH  - Tomography, X-Ray Computed
EDAT- 2010/05/18 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/05/18 06:00
PHST- 2009/09/17 00:00 [received]
PHST- 2009/11/05 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - S0360-3016(09)03676-1 [pii]
AID - 10.1016/j.ijrobp.2009.12.012 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):946-54. doi: 
      10.1016/j.ijrobp.2009.12.012. Epub 2010 May 14.