PMID- 20476978
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100610
LR  - 20100518
IS  - 1744-8409 (Electronic)
IS  - 1744-666X (Linking)
VI  - 2
IP  - 6
DP  - 2006 Nov
TI  - HLA genetics and disease with particular reference to Type 1 diabetes and HIV 
      infection in Asian Indians.
PG  - 901-13
LID - 10.1586/1744666X.2.6.901 [doi]
AB  - Recent compilation of the human genome sequence and studies on the structural 
      organization of molecules encoded in the human major histocompatibility complex 
      (MHC) have helped in defining the functional role of their gene products in the 
      host immune response. Confirmation of human leukocyte antigen (HLA) allele 
      association with prominent autoimmune and infectious diseases has rediscovered 
      the field with major efforts directed towards understanding the underlying 
      mechanisms. Sequence determination of the associated alleles and/or their 
      extended haplotypes explains how the peptides (pathogen-derived and/or 
      autoantigens) interact with specific pockets on the MHC motif for ultimate 
      inspection by the T cells. As there is a selective predominance of different HLA 
      alleles and haplotypes in different populations, a dedicated screening effort is 
      required at the global level to define the common HLA supertypes with shared 
      peptide-binding abilities. This could be a way forward for the design and 
      development of MHC-based vaccines against a variety of disease states.
FAU - Mehra, Narinder
AU  - Mehra N
AD  - All India Institute of Medical Sciences, Department of Transplant Immunology & 
      Immunogenetics Ansari Nagar New Delhi - 110 029, India. narin98@hotmail.com
FAU - Kaur, Gurvinder
AU  - Kaur G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Clin Immunol
JT  - Expert review of clinical immunology
JID - 101271248
EDAT- 2006/11/01 00:00
MHDA- 2006/11/01 00:01
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2006/11/01 00:00 [pubmed]
PHST- 2006/11/01 00:01 [medline]
AID - 10.1586/1744666X.2.6.901 [doi]
PST - ppublish
SO  - Expert Rev Clin Immunol. 2006 Nov;2(6):901-13. doi: 10.1586/1744666X.2.6.901.