PMID- 20477250
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100707
LR  - 20100518
IS  - 1747-6356 (Electronic)
IS  - 1747-6348 (Linking)
VI  - 2
IP  - 2
DP  - 2008 Apr
TI  - Role of dendritic cells in the lung: in vitro models, animal models and human 
      studies.
PG  - 215-33
LID - 10.1586/17476348.2.2.215 [doi]
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells in the human 
      lung and are now recognized as crucial initiators of immune responses in general. 
      They are arranged as sentinels in a dense surveillance network inside and below 
      the epithelium of the airways and alveoli, where they are ideally situated to 
      sample inhaled antigen. DCs are known to play a pivotal role in maintaining the 
      balance between tolerance and active immune response in the respiratory system. 
      It is no surprise that the lungs became a main focus of DC-related investigations 
      as this organ provides a large interface for interactions of inhaled antigens 
      with the human body. During recent years there has been a constantly growing body 
      of lung DC-related publications that draw their data from in vitro models, animal 
      models and human studies. This review focuses on the biology and functions of 
      different DC populations in the lung and highlights the advantages and drawbacks 
      of different models with which to study the role of lung DCs. Furthermore, we 
      present a number of up-to-date visualization techniques to characterize 
      DC-related cell interactions in vitro and/or in vivo.
FAU - Blank, Fabian
AU  - Blank F
AD  - Institute of Anatomy, Division of Histology, University of Berne, Baltzerstrasse 
      2, CH-3000 Berne 9, Switzerland. blank@ana.unibe.ch
FAU - von Garnier, Christophe
AU  - von Garnier C
FAU - Obregon, Carolina
AU  - Obregon C
FAU - Rothen-Rutishauser, Barbara
AU  - Rothen-Rutishauser B
FAU - Gehr, Peter
AU  - Gehr P
FAU - Nicod, Laurent
AU  - Nicod L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Respir Med
JT  - Expert review of respiratory medicine
JID - 101278196
EDAT- 2008/04/01 00:00
MHDA- 2008/04/01 00:01
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2008/04/01 00:00 [pubmed]
PHST- 2008/04/01 00:01 [medline]
AID - 10.1586/17476348.2.2.215 [doi]
PST - ppublish
SO  - Expert Rev Respir Med. 2008 Apr;2(2):215-33. doi: 10.1586/17476348.2.2.215.