PMID- 20477308
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100708
LR  - 20100518
IS  - 1747-6356 (Electronic)
IS  - 1747-6348 (Linking)
VI  - 3
IP  - 2
DP  - 2009 Apr
TI  - Coping with TB immune reconstitution inflammatory syndrome.
PG  - 147-52
LID - 10.1586/ers.09.8 [doi]
AB  - The TB immune reconstitution inflammatory syndrome (IRIS) is a relatively 
      frequent complication in HIV-TB-coinfected patients after they start highly 
      active antiretroviral therapy (HAART). There are two forms of TB IRIS: the 
      'paradoxical' type (clinical worsening of a patient on TB treatment) and the 
      'unmasking' type (undiagnosed TB becoming apparent after starting HAART). Their 
      pathogeneses are not fully understood, although, as the name suggests, IRIS 
      following initiation of HAART is accompanied by an increase in immune responses 
      to Mycobacterium tuberculosis. The diagnosis of TB IRIS is mainly clinical; so 
      far there are no laboratory tests able to diagnose or predict TB IRIS. Risk 
      factors for TB IRIS include a low CD4(+) lymphocyte count, disseminated TB 
      infection at HAART initiation and a short interval between TB treatment and HAART 
      initiation. TB IRIS complicates the treatment and care for HIV-TB-coinfected 
      patients. In this paper, we discuss some aspects of pathogenesis and options for 
      the treatment and prevention of TB IRIS.
FAU - Worodria, William
AU  - Worodria W
AD  - Department of Medicine/Infectious Disease Institute, Mulago Hospital, PO Box 
      7051, Kampala, Uganda. worodria@yahoo.com
FAU - Conesa-Botella, Anali
AU  - Conesa-Botella A
FAU - Kisembo, Harriet
AU  - Kisembo H
FAU - McAdam, Keith Pwj
AU  - McAdam KP
FAU - Colebunders, Robert
AU  - Colebunders R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Respir Med
JT  - Expert review of respiratory medicine
JID - 101278196
EDAT- 2010/05/19 06:00
MHDA- 2010/05/19 06:01
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/05/19 06:01 [medline]
AID - 10.1586/ers.09.8 [doi]
PST - ppublish
SO  - Expert Rev Respir Med. 2009 Apr;3(2):147-52. doi: 10.1586/ers.09.8.