PMID- 20482768
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20211020
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 10
DP  - 2010 May 18
TI  - Progressive multifocal leucoencephalopathy in an immunocompetent patient with 
      favourable outcome. A case report.
PG  - 32
LID - 10.1186/1471-2377-10-32 [doi]
AB  - BACKGROUND: To report the clinical course of PML in an apparently immunocompetent 
      patient treated with cidofovir. CASE PRESENTATION: A 35-year-old immunocompetent 
      man who developed progressive hemianopsia, aphasia, and limb weakness underwent 
      repeated MRI scans of the brain, spinal fluid analyses, and brain biopsy. Before 
      diagnosis was established based on brain biopsy, he was consecutively treated 
      with methylprednisolone, acyclovir, ceftriaxone and plasmapheresis, but he 
      deteriorated rapidly suggestive of the immune reconstitution inflammatory 
      syndrome (IRIS). He started to recover two weeks after the initiation of 
      treatment with cidofovir and has had no relapse at 3 1/2 years of follow-up. MRI 
      has shown marked improvement. CONCLUSIONS: PML should be considered in 
      immunocompetent patients with a typical clinical course and MRI findings 
      compatible with PML. Treatment with cidofovir should be considered as early as 
      possible in the disease course.
FAU - Naess, Halvor
AU  - Naess H
AD  - Department of Neurology, Haukeland University Hospital, N-5021 Bergen, Norway. 
      haln@haukeland.no
FAU - Glad, Solveig
AU  - Glad S
FAU - Storstein, Anette
AU  - Storstein A
FAU - Rinaldo, Christine H
AU  - Rinaldo CH
FAU - Mork, Sverre J
AU  - Mork SJ
FAU - Myhr, Kjell-Morten
AU  - Myhr KM
FAU - Hirsch, Hans
AU  - Hirsch H
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100518
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Adult
MH  - Humans
MH  - Immunocompetence/*physiology
MH  - Leukoencephalopathy, Progressive Multifocal/*diagnosis/*physiopathology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
PMC - PMC2880963
EDAT- 2010/05/21 06:00
MHDA- 2010/07/14 06:00
PMCR- 2010/05/18
CRDT- 2010/05/21 06:00
PHST- 2009/11/10 00:00 [received]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
PHST- 2010/05/18 00:00 [pmc-release]
AID - 1471-2377-10-32 [pii]
AID - 10.1186/1471-2377-10-32 [doi]
PST - epublish
SO  - BMC Neurol. 2010 May 18;10:32. doi: 10.1186/1471-2377-10-32.