PMID- 20482787
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20240517
IS  - 1471-2105 (Electronic)
IS  - 1471-2105 (Linking)
VI  - 11
DP  - 2010 May 18
TI  - Screensaver: an open source lab information management system (LIMS) for high 
      throughput screening facilities.
PG  - 260
LID - 10.1186/1471-2105-11-260 [doi]
AB  - BACKGROUND: Shared-usage high throughput screening (HTS) facilities are becoming 
      more common in academe as large-scale small molecule and genome-scale RNAi 
      screening strategies are adopted for basic research purposes. These shared 
      facilities require a unique informatics infrastructure that must not only provide 
      access to and analysis of screening data, but must also manage the administrative 
      and technical challenges associated with conducting numerous, interleaved 
      screening efforts run by multiple independent research groups. RESULTS: We have 
      developed Screensaver, a free, open source, web-based lab information management 
      system (LIMS), to address the informatics needs of our small molecule and RNAi 
      screening facility. Screensaver supports the storage and comparison of screening 
      data sets, as well as the management of information about screens, screeners, 
      libraries, and laboratory work requests. To our knowledge, Screensaver is one of 
      the first applications to support the storage and analysis of data from both 
      genome-scale RNAi screening projects and small molecule screening projects. 
      CONCLUSIONS: The informatics and administrative needs of an HTS facility may be 
      best managed by a single, integrated, web-accessible application such as 
      Screensaver. Screensaver has proven useful in meeting the requirements of the 
      ICCB-Longwood/NSRB Screening Facility at Harvard Medical School, and has provided 
      similar benefits to other HTS facilities.
FAU - Tolopko, Andrew N
AU  - Tolopko AN
AD  - ICCB-Longwood/NSRB Screening Facility, Harvard Medical School, 250 Longwood 
      Avenue, Boston, MA 02115, USA. andrew_tolopko@hms.harvard.edu
FAU - Sullivan, John P
AU  - Sullivan JP
FAU - Erickson, Sean D
AU  - Erickson SD
FAU - Wrobel, David
AU  - Wrobel D
FAU - Chiang, Su L
AU  - Chiang SL
FAU - Rudnicki, Katrina
AU  - Rudnicki K
FAU - Rudnicki, Stewart
AU  - Rudnicki S
FAU - Nale, Jennifer
AU  - Nale J
FAU - Selfors, Laura M
AU  - Selfors LM
FAU - Greenhouse, Dara
AU  - Greenhouse D
FAU - Muhlich, Jeremy L
AU  - Muhlich JL
FAU - Shamu, Caroline E
AU  - Shamu CE
LA  - eng
GR  - U54 AI057159/AI/NIAID NIH HHS/United States
GR  - U19 AI067751/AI/NIAID NIH HHS/United States
GR  - U01 TW007404/TW/FIC NIH HHS/United States
GR  - P01 CA78048/CA/NCI NIH HHS/United States
GR  - U19 CA128534/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100518
PL  - England
TA  - BMC Bioinformatics
JT  - BMC bioinformatics
JID - 100965194
SB  - IM
MH  - *Database Management Systems
MH  - Drug Discovery
MH  - Genome
MH  - RNA Interference
MH  - *Software
MH  - User-Computer Interface
PMC - PMC3001403
EDAT- 2010/05/21 06:00
MHDA- 2010/10/28 06:00
PMCR- 2010/05/18
CRDT- 2010/05/21 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
PHST- 2010/05/18 00:00 [pmc-release]
AID - 1471-2105-11-260 [pii]
AID - 10.1186/1471-2105-11-260 [doi]
PST - epublish
SO  - BMC Bioinformatics. 2010 May 18;11:260. doi: 10.1186/1471-2105-11-260.