PMID- 20483468 OWN - NLM STAT- MEDLINE DCOM- 20110104 LR - 20101025 IS - 0165-1781 (Print) IS - 0165-1781 (Linking) VI - 180 IP - 1 DP - 2010 Nov 30 TI - The role of genetic variation of BDNF gene in antidepressant-induced mania in bipolar disorder. PG - 54-6 LID - 10.1016/j.psychres.2010.04.036 [doi] AB - The occurrence of mania during antidepressant treatment is a key issue in the clinical management of bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of mood disorders. Moreover, antidepressants increase the expression of BDNF and its overactivity may be involved in the mechanism of development of the manic state. The aim of the present study was to test the influence of BDNF gene alterations in antidepressant-induced mania in bipolar patients. A case-control study was performed to analyse genotype and allele frequencies for the BDNF polymorphisms between two groups [37 patients with antidepressant-induced mania (AIM+) and 55 patients without antidepressant-induced mania (AIM-)]. No significant differences were found between AIM+ and AIM- groups. Our results did not support the BDNF gene link to antidepressant-induced mania, like a previous study with a smaller sample has already suggested. CI - Copyright (c) 2010 Elsevier Ltd. All rights reserved. FAU - de Aguiar Ferreira, Alexandre AU - de Aguiar Ferreira A AD - Neuroscience Program, Institute of Biological Sciences, Federal University of Minas Gerais (ICB-UFMG), Belo Horizonte, Brazil. FAU - Neves, Fernando Silva AU - Neves FS FAU - Pimenta, Guilherme Jose Garcia Santos AU - Pimenta GJ FAU - Mello, Marina Pena AU - Mello MP FAU - Miranda, Debora Marques AU - Miranda DM FAU - Romano-Silva, Marco Aurelio AU - Romano-Silva MA FAU - De Marco, Luiz Armando AU - De Marco LA FAU - Correa, Humberto AU - Correa H LA - eng PT - Journal Article DEP - 20100518 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Antidepressive Agents/*adverse effects MH - Bipolar Disorder/*chemically induced/drug therapy/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Case-Control Studies MH - Chi-Square Distribution MH - Female MH - Gene Frequency MH - Genotype MH - Humans MH - Male MH - Polymorphism, Genetic/*genetics EDAT- 2010/05/21 06:00 MHDA- 2011/01/05 06:00 CRDT- 2010/05/21 06:00 PHST- 2008/11/18 00:00 [received] PHST- 2010/03/08 00:00 [revised] PHST- 2010/04/21 00:00 [accepted] PHST- 2010/05/21 06:00 [entrez] PHST- 2010/05/21 06:00 [pubmed] PHST- 2011/01/05 06:00 [medline] AID - S0165-1781(10)00195-2 [pii] AID - 10.1016/j.psychres.2010.04.036 [doi] PST - ppublish SO - Psychiatry Res. 2010 Nov 30;180(1):54-6. doi: 10.1016/j.psychres.2010.04.036. Epub 2010 May 18.