PMID- 20483746
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20131121
IS  - 1550-6606 (Electronic)
IS  - 0022-1767 (Linking)
VI  - 184
IP  - 12
DP  - 2010 Jun 15
TI  - Immunosuppressive effect of quercetin on dendritic cell activation and function.
PG  - 6815-21
LID - 10.4049/jimmunol.0903991 [doi]
AB  - Dendritic cells (DCs) play a crucial role in linking innate and adaptive 
      immunity. Thus, DCs have been regarded as a major target of immunosuppressants 
      for the control of harmful immune responses. In this study, we examined the 
      effect of quercetin, a natural flavonoid found in many vegetables and fruits, on 
      the activation and function of mouse DCs. Quercetin effectively inhibited 
      LPS-induced DC activation by reducing the production of proinflammatory 
      cytokines/chemokines and the expression levels of MHC class II and costimulatory 
      molecules. In addition, quercetin uniquely blocked endocytosis by DCs and the 
      LPS-induced DC migration was diminished by quercetin treatment. Furthermore, 
      quercetin abrogated the ability of LPS-stimulated DCs to induce Ag-specific T 
      cell activation, both in vitro and in vivo. Remarkably, coadministration of 
      quercetin with 2,4-dinitro-1-fluorobenzene prevented 
      2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity, indicating the 
      potential of quercetin for treating delayed-type hypersensitive diseases. 
      Blockage of LPS-induced ERK, JNK, Akt, and NF-kappaB activation contributed to 
      the inhibitory effect of quercetin on DCs. These results strongly suggest that 
      quercetin may be a potent immunosuppressive agent and could be used in the 
      prevention and therapy of chronic inflammation, autoimmunity, and transplantation 
      via the abolishment of DC activation and function.
FAU - Huang, Ren-Yeong
AU  - Huang RY
AD  - Graduate Institute of Medical Sciences and Department of Periodontology, School 
      of Dentistry, National Defense Medical Center and Tri-Service General Hospital, 
      Taipei, Taiwan.
FAU - Yu, Yen-Ling
AU  - Yu YL
FAU - Cheng, Wan-Chien
AU  - Cheng WC
FAU - OuYang, Chun-Nan
AU  - OuYang CN
FAU - Fu, Earl
AU  - Fu E
FAU - Chu, Ching-Liang
AU  - Chu CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100517
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Cytokines/immunology
MH  - Dendritic Cells/*drug effects/immunology
MH  - Endocytosis/drug effects
MH  - Immunosuppressive Agents/*pharmacology
MH  - Lymphocyte Activation/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Quercetin/*pharmacology
MH  - Signal Transduction/drug effects/immunology
MH  - T-Lymphocytes/drug effects/immunology
EDAT- 2010/05/21 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - jimmunol.0903991 [pii]
AID - 10.4049/jimmunol.0903991 [doi]
PST - ppublish
SO  - J Immunol. 2010 Jun 15;184(12):6815-21. doi: 10.4049/jimmunol.0903991. Epub 2010 
      May 17.