PMID- 20485144
OWN - NLM
STAT- MEDLINE
DCOM- 20100609
LR  - 20221207
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 251
IP  - 6
DP  - 2010 Jun
TI  - Long-term follow-up of the metabolic profiles in obese patients with type 2 
      diabetes mellitus after Roux-en-Y gastric bypass.
PG  - 1049-55
LID - 10.1097/SLA.0b013e3181d9769b [doi]
AB  - OBJECTIVE: The goal of this study was to evaluate the effect of Roux-en-Y gastric 
      bypass (RYGBP) on 2 metabolic disorders, diabetes and dyslipidemia, in obese type 
      2 diabetes mellitus (T2DM) patients. SUMMARY BACKGROUND DATA: Little is known 
      about the long-term change in metabolic and lipid profiles of T2DM patients after 
      RYGBP. METHODS: This is a retrospective review of prospectively collected data 
      about glucose metabolism and lipid profiles of morbidly obese patients with T2DM 
      on antidiabetic medications who underwent laparoscopic RYGBP. RESULTS: A total 
      219 patients with mean (+/-SD) duration of follow-up of 26.4 (+/-12.8) months 
      were included in the study. At one year postoperative mean serum fasting plasma 
      glucose fell from 152.8 to 106.0 mg/dL, HGBA1c (glycated hemoglobin) fell from 
      7.6% to 6.1%, TC (total cholesterol) went from 180.9 to 172.0 mg/dL, TG 
      (triglyceride) fell from 208.0 to 117.4 mg/dL, and HDL-C (HDL-cholesterol) levels 
      increased from 48.7 to 58.7 mg/dL. These improvements were maintained 2 to 4 
      years after surgery. Older age, longer duration of T2DM, and insulin use were 
      important preoperative factors associated with failure to resolve T2DM. 
      Postoperatively, the amount of total weight loss was associated with the 
      improvement or resolution of T2DM (P = 0.053). CONCLUSION: Laparoscopic RYGBP has 
      a beneficial effect on glucose metabolism and serum lipid composition in obese 
      T2DM patients. Sustained weight loss was associated with maintenance of 
      euglycemia in postoperative obese T2DM patients.
FAU - Kim, Seongmin
AU  - Kim S
AD  - Division of Pediatric Surgery, Department of Surgery, Yonsei University College 
      of Medicine, Seoul, Korea.
FAU - Richards, William O
AU  - Richards WO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Dyslipidemias/*blood/complications
MH  - Female
MH  - *Gastric Bypass
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/blood/complications/*surgery
MH  - Weight Loss
MH  - Young Adult
EDAT- 2010/05/21 06:00
MHDA- 2010/06/10 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/10 06:00 [medline]
AID - 10.1097/SLA.0b013e3181d9769b [doi]
PST - ppublish
SO  - Ann Surg. 2010 Jun;251(6):1049-55. doi: 10.1097/SLA.0b013e3181d9769b.