PMID- 20485159
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20221207
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Aug
TI  - Genetic and ethnic risk factors associated with drug hypersensitivity.
PG  - 280-90
LID - 10.1097/ACI.0b013e32833b1eb3 [doi]
AB  - PURPOSE OF REVIEW: The purpose of this article is to review the recent findings 
      of studies reporting on the genetic and ethnic factors associated with 
      hypersensitivity reactions to common drugs such as acetyl salicylic acid/NSAIDs, 
      antibiotics, antituberculus medications, and other drugs including carbamazepine 
      (CBZ), abacarvir, and allopurinol that can cause severe hypersensitivity 
      reactions. RECENT FINDINGS: Aspirin hypersensitivity has recently been associated 
      with a variety of genetic polymorphisms associated with leukotriene 
      overproduction, eosinophil infiltration, and histamine-related genes. Recently, 
      beta-lactam antibiotic hypersensitivity has been reported to be associated with 
      interleukin (IL)-4 and IL-13 receptors in Italian, Chinese, and French 
      populations. Moreover, a significant association of CYP2E1 in the Chinese, NAT2 
      in Koreans and glutathione S-transferase genotypes in Caucasians has been 
      reported with antituberculus drug-induced hepatitis. The association of the 
      HLA-B*1502 allele with CBZ-induced Stevens-Johnson syndrome in Asian population 
      has also recently been observed. SUMMARY: Aspirin hypersensitivity has been 
      associated with various genetic polymorphisms. Human leukocyte antigen 
      (HLA)-related markers and a variety of genetic polymorphisms of 
      leukotriene-related genes, eosinophil-related genes, and genes associated with 
      immune function have been described according to ethnicity. The genetic 
      mechanisms of antibiotic hypersensitivity have been reported in Italian, French, 
      and Chinese populations in addition to antibiotics-induced cutaneous reactions in 
      the Korean population. Most prior genetic studies on antituberculus drug-induced 
      hepatitis have focused on a few drug-metabolizing enzymes such as cytochrome P450 
      and N-acetyltransferase 2. HLA-related markers associated with CBZ, lamotrigine, 
      and abacavir-induced severe hypersensitivity reactions have been described.
FAU - Kim, Seung-Hyun
AU  - Kim SH
AD  - Department of Allergy & Rheumatology, Ajou University School of Medicine, Suwon, 
      South Korea.
FAU - Ye, Young-Min
AU  - Ye YM
FAU - Palikhe, Nami Shrestha
AU  - Palikhe NS
FAU - Kim, Jeong-Eun
AU  - Kim JE
FAU - Park, Hae-Sim
AU  - Park HS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
SB  - IM
MH  - Asian People/genetics
MH  - Drug Hypersensitivity/*ethnology/etiology/*genetics
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Risk Factors
MH  - White People/genetics
EDAT- 2010/05/21 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.1097/ACI.0b013e32833b1eb3 [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):280-90. doi: 
      10.1097/ACI.0b013e32833b1eb3.