PMID- 20486174
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20100520
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 55
IP  - 1
DP  - 2010 Jul 15
TI  - Serum derivative of reactive oxygen metabolites (d-ROMs) in pediatric 
      hemato-oncological patients with neutropenic fever.
PG  - 91-4
LID - 10.1002/pbc.22507 [doi]
AB  - BACKGROUND: Early markers for predicting the severity of neutropenic fever (NF) 
      in patients with hemato-oncological patients have not yet been established. 
      Reactive oxygen species are known to play an important role in the antimicrobial 
      function of neutrophils. The aim of this study was to determine the serum levels 
      of derivatives of reactive oxygen metabolites (d-ROMs) and the biological 
      antioxidant potential (BAP) levels in these patients, and to investigate the 
      associations between these levels and the severity of NF. PROCEDURE: Twenty-seven 
      pediatric hemato-oncological patients were enroled in this prospective study. 
      Their median age was 10 years (range 1-19). Laboratory samples for C-reactive 
      protein (CRP), d-ROMs, and BAP were collected at the onset of NF. The Free 
      Radical Analytical System 4(R) was used to measure levels of d-ROMs and BAP. 
      RESULTS: A total 36 NF episodes were evaluated. Levels of d-ROMs in NF patients 
      with systemic inflammatory response syndrome (SIRS, n = 7) were significantly 
      lower than those in subjects without SIRS (n = 29; 197.6 vs. 314.1 U.CARR, P = 
      0.017). There were no statistically significant differences in CRP, BAP, WBC 
      count, or neutrophil count at the onset. The peak levels of CRP were 
      significantly higher in patients with SIRS than in those without SIRS (23.9 vs. 
      6.1 mg/dl, P = 0.0003). CONCLUSION: Patients with low level of d-ROMs at the 
      onset of NF should be observed stringently since they possibly have severe NF.
FAU - Nishikawa, Takuro
AU  - Nishikawa T
AD  - Department of Pediatrics, Kagoshima University Graduate School of Medical and 
      Dental Sciences, Kagoshima, Japan. adu44150@ams.odn.ne.jp
FAU - Okamoto, Yasuhiro
AU  - Okamoto Y
FAU - Kodama, Yuichi
AU  - Kodama Y
FAU - Tanabe, Takayuki
AU  - Tanabe T
FAU - Shinkoda, Yuichi
AU  - Shinkoda Y
FAU - Kawano, Yoshifumi
AU  - Kawano Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (Antioxidants)
RN  - 0 (Free Radicals)
RN  - 0 (Reactive Oxygen Species)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antioxidants/analysis/metabolism
MH  - C-Reactive Protein/analysis/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fever/*blood/diagnosis
MH  - Free Radicals/metabolism
MH  - Hematologic Neoplasms/*blood/diagnosis
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neutropenia/*blood/diagnosis
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reactive Oxygen Species/*blood/metabolism
MH  - Young Adult
EDAT- 2010/05/21 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - 10.1002/pbc.22507 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2010 Jul 15;55(1):91-4. doi: 10.1002/pbc.22507.