PMID- 2048775
OWN - NLM
STAT- MEDLINE
DCOM- 19910716
LR  - 20190907
IS  - 0090-6964 (Print)
IS  - 0090-6964 (Linking)
VI  - 19
IP  - 2
DP  - 1991
TI  - In vitro validation of a right ventricular thermodilution ejection fraction 
      system.
PG  - 165-77
AB  - Right ventricular ejection fraction (RVEF) is used clinically as an index of 
      right ventricular (RV) pump function. Clinical measurements of RVEF are 
      complicated by the need for complex imaging equipment to compute RV volumes. 
      Recently, the use of thermodilution (TD) methods have been suggested as a 
      simplified means to measure RVEF (RVEFTD) in patients using rapid response 
      thermistors. Validation, however, by comparison of RVEFTD and other methods in 
      vivo, is difficult. Accordingly, thermodilution derived EF measurements (EFTD) 
      were compared to known values using an in vitro system, with known ejection 
      fractions (EF) set from 17-78% and stroke rates varying independently from 50-100 
      strokes/min. EFTD was computed by fitting the downslope of the TD curve to a 
      monoexponential function and computing the time constant of thermal decay. A 
      significant correlation existed between EFTD and actual EF over the entire study 
      (r = 0.96, p less than 0.001). Bias analysis showed that the points were within a 
      95% confidence interval of +/- 12%. Multivariate analysis showed that stroke rate 
      did not significantly affect TD measurements (r = 0.03, p greater than 0.7). This 
      study demonstrates that TD accurately predicts EF using an in vitro system and 
      appears to be independent of stroke rate. Thus, TD methods may provide an 
      accurate, simple and reliable means to serially measure RVEF in the clinical 
      setting.
FAU - Mukherjee, R
AU  - Mukherjee R
AD  - Division of Cardiothoracic Surgery, Medical University of South Carolina, 
      Charleston 29425.
FAU - Spinale, F G
AU  - Spinale FG
FAU - von Recum, A F
AU  - von Recum AF
FAU - Crawford, F A
AU  - Crawford FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Biomed Eng
JT  - Annals of biomedical engineering
JID - 0361512
SB  - IM
MH  - Algorithms
MH  - *Models, Cardiovascular
MH  - *Stroke Volume
MH  - Thermodilution/*methods
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1007/BF02368467 [doi]
PST - ppublish
SO  - Ann Biomed Eng. 1991;19(2):165-77. doi: 10.1007/BF02368467.