PMID- 20488200
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20161125
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 34
IP  - 10
DP  - 2010 Oct
TI  - Correlated expression profile of extracellular matrix-related molecules during 
      the inflammatory response of the teleost fish gilthead seabream.
PG  - 1051-8
LID - 10.1016/j.dci.2010.05.007 [doi]
AB  - Extracellular matrix (ECM) components, in addition to their structural functions, 
      interact with cell surface receptors and intracellular components to modulate the 
      transduction of signals for cell growth, differentiation, migration, 
      proliferation, polarization, apoptosis and inflammation. Our previous findings in 
      the gilthead seabream (Sparus aurata L.), a marine seasonal hermaphrodite teleost 
      fish, have shown that both endocrine and immune stimuli modulate the expression 
      of matrix metalloproteases (MMPs) and tissue inhibitors of MMP (TIMPs). In 
      addition, collagen type I (COL1) induces the expression of some pro-inflammatory 
      cytokines and MMPs in professional phagocytes. Consequently, in this study we use 
      real-time RT-PCR to analyze the gene expression profile of several ECM-related 
      molecules (MMP-2, -9 and -13, TIMP-2a, and -2b, COL1A1, and integrin beta1a) in 
      different organs of adult specimens as well as in response to innate immune 
      challenges. Our results showed that liver had the lowest basal levels of them, 
      although they were clearly modulated during injury and infection. In the same 
      way, ECM-related molecules seem to participate in pro-inflammatory processes, 
      being of particular interest COL1 which is synthesized by immune cells and is 
      able to act as autocrine/paracrine stimulus for them. Lastly, we propose that the 
      observed correlations between ECM-related molecules during the inflammatory 
      response should be considered to obtain a more accurate picture of their roles in 
      this process.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Castillo-Briceno, Patricia
AU  - Castillo-Briceno P
AD  - Department of Cell Biology and Histology, University of Murcia, Murcia 30100, 
      Spain.
FAU - Arizcun-Arizcun, Marta
AU  - Arizcun-Arizcun M
FAU - Meseguer, Jose
AU  - Meseguer J
FAU - Mulero, Victoriano
AU  - Mulero V
FAU - Garcia-Ayala, Alfonsa
AU  - Garcia-Ayala A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Fish Proteins)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Chemical and Drug Induced Liver Injury/genetics/*immunology/metabolism
MH  - Extracellular Matrix Proteins/genetics/immunology/*metabolism
MH  - Fish Diseases/genetics/*immunology/metabolism
MH  - Fish Proteins/genetics/immunology/*metabolism
MH  - Gene Expression Profiling
MH  - Immunity, Innate
MH  - Inflammation
MH  - Liver/drug effects/immunology/*metabolism/pathology
MH  - Progesterone/administration & dosage
MH  - *Sea Bream
MH  - Signal Transduction/immunology
MH  - Vibrio/*immunology/pathogenicity
MH  - Vibrio Infections/genetics/*immunology/metabolism
EDAT- 2010/05/22 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2010/05/10 00:00 [revised]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0145-305X(10)00120-5 [pii]
AID - 10.1016/j.dci.2010.05.007 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2010 Oct;34(10):1051-8. doi: 10.1016/j.dci.2010.05.007. Epub 
      2010 May 26.