PMID- 20490362
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240312
IS  - 1945-7928 (Print)
IS  - 1945-8452 (Electronic)
IS  - 1945-7928 (Linking)
VI  - 2008
DP  - 2008 May 14
TI  - ROBUST MAXIMUM LIKELIHOOD ESTIMATION IN Q-SPACE MRI.
PG  - 867-870
AB  - Q-space imaging is an emerging diffusion weighted MR imaging technique to 
      estimate molecular diffusion probability density functions (PDF's) without the 
      need to assume a Gaussian distribution. We present a robust M-estimator, Q-space 
      Estimation by Maximizing Rician Likelihood (QEMRL), for diffusion PDF's based on 
      maximum likelihood. PDF's are modeled by constrained Gaussian mixtures. In QEMRL, 
      robust likelihood measures mitigate the impacts of imaging artifacts. In 
      simulation and in vivo human spinal cord, the method improves reliability of 
      estimated PDF's and increases tissue contrast. QEMRL enables more detailed 
      exploration of the PDF properties than prior approaches and may allow 
      acquisitions at higher spatial resolution.
FAU - Landman, B A
AU  - Landman BA
AD  - Johns Hopkins University School of Medicine and Kennedy Krieger Institute 
      Biomedical Engineering, Biophysics, Neurology, Radiology, and the F.M. Kirby 
      Center Baltimore, Maryland, USA.
FAU - Farrell, J A D
AU  - Farrell JA
FAU - Smith, S A
AU  - Smith SA
FAU - Calabresi, P A
AU  - Calabresi PA
FAU - van Zijl, P C M
AU  - van Zijl PC
FAU - Prince, J L
AU  - Prince JL
LA  - eng
GR  - R01 AG020012/AG/NIA NIH HHS/United States
GR  - P41 RR015241-02/RR/NCRR NIH HHS/United States
GR  - P41 RR015241/RR/NCRR NIH HHS/United States
GR  - P41 EB015909/EB/NIBIB NIH HHS/United States
GR  - R01 AG020012-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Proc IEEE Int Symp Biomed Imaging
JT  - Proceedings. IEEE International Symposium on Biomedical Imaging
JID - 101492570
PMC - PMC2872926
MID - NIHMS174929
EDAT- 2008/05/14 00:00
MHDA- 2008/05/14 00:01
PMCR- 2010/05/19
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2008/05/14 00:00 [pubmed]
PHST- 2008/05/14 00:01 [medline]
PHST- 2010/05/19 00:00 [pmc-release]
AID - 10.1109/isbi.2008.4541134 [doi]
PST - ppublish
SO  - Proc IEEE Int Symp Biomed Imaging. 2008 May 14;2008:867-870. doi: 
      10.1109/isbi.2008.4541134.