PMID- 20490717
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20220318
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Dec
TI  - Review and pooled analysis of studies on -607(C/A) and -137(G/C) polymorphisms in 
      IL-18 and cancer risk.
PG  - 1107-15
LID - 10.1007/s12032-010-9569-1 [doi]
AB  - Interleukin-18 (IL-18) is a pleiotropic, pro-inflammatory cytokine with dual 
      effects on tumor development and progression. The -607(C/A) and -137(G/C) 
      polymorphisms in IL-18 gene region have been implicated in cancer risk; however, 
      data from published studies with individually low statistical power are 
      conflicting. To clarify the role of IL-18 -607(C/A) and -137(G/C) genotype in 
      global cancer, we examined all the available published studies through a pooled 
      analysis approach. Overall, IL-18 -607A allele was associated with increased 
      total cancer risk when compared with -607C allele (OR=1.14, 95% CI=1.01-1.28, 
      P=0.010), as well as in the heterozygote comparison (OR=1.10, 95% CI=1.04-1.15, 
      P=0.256) and the dominant model (OR=1.07, 95% CI=1.03-1.11, P=0.124). 
      Furthermore, IL-18 -137(G/C) polymorphism was associated with increased 
      nasopharyngeal carcinoma risk. In the stratified analysis for -607(C/A) 
      polymorphism, a significantly increased cancer risk in Asian population was 
      found, as well as subgroup in source of control. Similar results were found in 
      the stratified analysis for -137(G/C) polymorphism. Our pooled analysis supported 
      that IL-18 is a good candidate for large-scale epidemiological case-control 
      studies that may be a low-penetrance susceptibility biomarker for cancer.
FAU - Mi, Yuan-Yuan
AU  - Mi YY
AD  - Department of Urology, First Affiliated Hospital of Nanjing Medical University, 
      300 Guangzhou Road, 210029, Nanjing, China.
FAU - Yu, Qian-Qian
AU  - Yu QQ
FAU - Yu, Meng-Lei
AU  - Yu ML
FAU - Xu, Bin
AU  - Xu B
FAU - Zhang, Li-Feng
AU  - Zhang LF
FAU - Cheng, Wei
AU  - Cheng W
FAU - Zhang, Wei
AU  - Zhang W
FAU - Hua, Li-Xin
AU  - Hua LX
FAU - Feng, Ning-Han
AU  - Feng NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100520
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Neoplasms/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2010/05/22 06:00
MHDA- 2012/03/23 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/04/29 00:00 [received]
PHST- 2010/05/05 00:00 [accepted]
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1007/s12032-010-9569-1 [doi]
PST - ppublish
SO  - Med Oncol. 2011 Dec;28(4):1107-15. doi: 10.1007/s12032-010-9569-1. Epub 2010 May 
      20.