PMID- 20491332
OWN - NLM
STAT- MEDLINE
DCOM- 20100702
LR  - 20100524
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 28
IP  - 166
DP  - 2010 Apr
TI  - [The assessment of neopterin concentration in patients with heart failure].
PG  - 256-9
AB  - Blood serum concentration of neopterin provides knowledge about current cells 
      immunological respond and might be used as a predictor of the progression in many 
      disorders. THE AIM OF THE STUDY was the assessment of the blood serum 
      concentration of neopterin in patients with heart failure and evaluation if there 
      is any correlation between this protein and the stage and etiology of chronic 
      heart failure (CHF). MATERIAL AND METHODS: 47 patients with chronic heart failure 
      were studied. They were divided into two subgroups: 21 patients with the etiology 
      of CHF caused by hypertension and 26 patients with the etiology of CHF caused by 
      ischemic heart disease. Based on the clinical symptoms patients, 19 of them were 
      connected into the II class and 28 into the III class of heart failure according 
      to the New York Heart Association (NYHA) functional classification system. 
      Control group was 20 healthy volunteers. Blood serum concentration of neopterin 
      had been assessed using radioimmunological method. RESULTS: The concentration of 
      neopterin was statistically higher in group of patient with CHF. No correlation 
      between concentration of neopterin and the etiology of CHF had been observed. 
      Concentration of neopterin in patient with class III NYHA of heart failure was 
      significantly higher than in group of patient with class II. CONCLUSIONS: Chronic 
      heart failure is associated with elevated blood serum concentration of neopterin. 
      Serum concentration of neopterin does not depend on the etiology of heart 
      failure. Heart failure progression increases neopterin concentration. In clinical 
      practice blood serum concentration of neopterin could be considered as a 
      prognostic factor for patients with heart insufficiency.
FAU - Wetlicka, Irmina
AU  - Wetlicka I
AD  - Uniwersytet Medyczny w Poznaniu: Zaklad Farmakologii Klinicznej Katedry 
      Kardiologii.
FAU - Korzeniowska, Katarzyna
AU  - Korzeniowska K
FAU - Bogdanski, Pawel
AU  - Bogdanski P
FAU - Kazmierczak, Miroslaw
AU  - Kazmierczak M
FAU - Chmara, Ewa
AU  - Chmara E
FAU - Musialik, Katarzyna
AU  - Musialik K
FAU - Jablecka, Anna
AU  - Jablecka A
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Ocena stezenia neopteryny u chorych z niewydolnoscia serca.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 670-65-5 (Neopterin)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Disease Progression
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neopterin/*blood
MH  - Prognosis
EDAT- 2010/05/25 06:00
MHDA- 2010/07/03 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/07/03 06:00 [medline]
PST - ppublish
SO  - Pol Merkur Lekarski. 2010 Apr;28(166):256-9.