PMID- 20491435
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20100611
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 44
IP  - 12
DP  - 2010 Jun 15
TI  - Partitioning of persistent organic pollutants between blubber and blood of wild 
      bottlenose dolphins: implications for biomonitoring and health.
PG  - 4789-95
LID - 10.1021/es1004158 [doi]
AB  - Biomonitoring surveys of wild cetaceans commonly utilize blubber as a means to 
      assess exposure to persistent organic pollutants (POPs), but the relationship 
      between concentrations in blubber and those in blood, a better indicator of 
      target organ exposure, is poorly understood. To define this relationship, matched 
      blubber and plasma samples (n = 56) were collected from free-ranging bottlenose 
      dolphins (Tursiops truncatus) and analyzed for 61 polychlorinated biphenyl (PCB) 
      congeners, 5 polybrominated diphenyl ether (PBDE) congeners, and 13 
      organochlorine pesticides (OCPs). With the exception of PCB 209, lipid-normalized 
      concentrations of the major POPs in blubber and plasma were positively and 
      significantly correlated (R(2) = 0.828 to 0.976). Plasma concentrations, however, 
      significantly increased with declining blubber lipid content, suggesting that as 
      lipid is utilized, POPs are mobilized into blood. Compound- and homologue- 
      specific blubber/blood partition coefficients also differed according to lipid 
      content, suggesting POPs are selectively mobilized from blubber. Overall, these 
      results suggest that with the regression parameters derived here, blubber may be 
      used to estimate blood concentrations and vice versa. Additionally, the 
      mobilization of lipid from blubber and concomitant increase in contaminants in 
      blood suggests cetaceans with reduced blubber lipid may be at greater risk for 
      contaminant-associated health effects.
FAU - Yordy, Jennifer E
AU  - Yordy JE
AD  - Hollings Marine Laboratory, National Institute of Standards and Technology, 331 
      Fort Johnson Road, Charleston, South Carolina 29412, USA. jennifer.yordy@noaa.gov
FAU - Wells, Randall S
AU  - Wells RS
FAU - Balmer, Brian C
AU  - Balmer BC
FAU - Schwacke, Lori H
AU  - Schwacke LH
FAU - Rowles, Teri K
AU  - Rowles TK
FAU - Kucklick, John R
AU  - Kucklick JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Animal Structures/*metabolism
MH  - Animals
MH  - Bottle-Nosed Dolphin/*blood
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - *Health
MH  - Lipids/analysis
MH  - Male
MH  - Organic Chemicals/*blood
MH  - Regression Analysis
MH  - Tissue Distribution
EDAT- 2010/05/25 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - 10.1021/es1004158 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2010 Jun 15;44(12):4789-95. doi: 10.1021/es1004158.