PMID- 20491627
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211203
IS  - 1875-5550 (Electronic)
IS  - 1389-2037 (Print)
IS  - 1389-2037 (Linking)
VI  - 11
IP  - 6
DP  - 2010 Sep
TI  - The complexes of mammalian target of rapamycin.
PG  - 409-24
AB  - The mammalian target of rapamycin (mTOR) has attracted substantial attention 
      because of its involvement in a variety of diseases, such as cancer, cardiac 
      hypertrophy, diabetes and obesity. Current knowledge indicates that mTOR 
      functions as two distinct multiprotein complexes, mTORC1 and mTORC2. mTORC1 
      phosphorylates p70 S6 kinase (S6K1) and eukaryotic initiation factor 4E (eIF4E) 
      binding protein 1 (4E-BP1), and regulates cell growth, proliferation, and 
      survival by integrating hormones, growth factors, nutrients, stressors and energy 
      signals. In contrast, mTORC2 is insensitive to nutrients or energy conditions. 
      However, in response to hormones or growth factors, mTORC2 phosphorylates Akt, 
      and regulates actin cytoskeleton and cell survival. These findings not only 
      reveal the crucial role of mTOR in physiology and pathology, but also reflect the 
      complexity of the mTOR signaling network. In this review, we discuss the advances 
      in studies of the mTOR complexes, including the interacting proteins, the 
      upstream regulators and the downstream effectors of mTOR complexes, as well as 
      their implication in certain human diseases.
FAU - Zhou, Hongyu
AU  - Zhou H
AD  - Department of Biochemistry and Molecular Biology, Louisiana State University 
      Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA.
FAU - Huang, Shile
AU  - Huang S
LA  - eng
GR  - R01 CA115414/CA/NCI NIH HHS/United States
GR  - R01 CA115414-04/CA/NCI NIH HHS/United States
GR  - CA115414/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Protein Pept Sci
JT  - Current protein & peptide science
JID - 100960529
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Cell Proliferation
MH  - Models, Biological
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC2928868
MID - NIHMS183056
COIS- Conflict of interest statement None declared.
EDAT- 2010/05/25 06:00
MHDA- 2011/03/01 06:00
PMCR- 2011/09/01
CRDT- 2010/05/25 06:00
PHST- 2010/10/16 00:00 [received]
PHST- 2010/05/20 00:00 [accepted]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - CPPS-56 [pii]
AID - 10.2174/138920310791824093 [doi]
PST - ppublish
SO  - Curr Protein Pept Sci. 2010 Sep;11(6):409-24. doi: 10.2174/138920310791824093.