PMID- 20492298
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20240109
IS  - 1750-3841 (Electronic)
IS  - 0022-1147 (Linking)
VI  - 75
IP  - 3
DP  - 2010 Apr
TI  - Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential 
      oil on eosinophils.
PG  - H87-92
LID - 10.1111/j.1750-3841.2010.01541.x [doi]
AB  - Yuzu (Citrus junos Tanaka) has been used as a traditional medicine in Japan. We 
      investigated in vitro anti-inflammatory effects of limonene from yuzu peel on 
      human eosinophilic leukemia HL-60 clone 15 cells. To examine anti-inflammatory 
      effects of limonene on the cells, we measured the level of reactive oxygen 
      species (ROS), monocyte chemoattractant protein-1 (MCP-1), nuclear factor (NF) 
      kappa B, and p38 mitogen-activated protein kinase (MAPK). We found that low 
      concentration of limonene (7.34 mmol/L) inhibited the production of ROS for 
      eotaxin-stimulated HL-60 clone 15 cells. 14.68 mmol/L concentration of limonene 
      diminished MCP-1 production via NF-kappa B activation comparable to the addition 
      of the proteasomal inhibitor MG132. In addition, it inhibited cell chemotaxis in 
      a p38 MAPK dependent manner similar to the adding of SB203580. These results 
      suggest that limonene may have potential anti-inflammatory efficacy for the 
      treatment of bronchial asthma by inhibiting cytokines, ROS production, and 
      inactivating eosinophil migration.
FAU - Hirota, Ryoji
AU  - Hirota R
AD  - Dept. of Environmental Medicine, Kochi Medical School, Kohasu, Oko, Nankoku, 
      Kochi 783-8505, Japan. hirotar@kochi-u.ac.jp
FAU - Roger, Ngatu Nlandu
AU  - Roger NN
FAU - Nakamura, Hiroyuki
AU  - Nakamura H
FAU - Song, Hee-Sun
AU  - Song HS
FAU - Sawamura, Masayoshi
AU  - Sawamura M
FAU - Suganuma, Narufumi
AU  - Suganuma N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Food Sci
JT  - Journal of food science
JID - 0014052
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cyclohexenes)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Oils, Volatile)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Terpenes)
RN  - 9MC3I34447 (Limonene)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Asthma/drug therapy
MH  - Cell Movement/drug effects
MH  - Chemokine CCL2/metabolism
MH  - Citrus/*chemistry
MH  - Cyclohexenes/*pharmacology
MH  - DNA-Binding Proteins/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Eosinophils/*drug effects/immunology/metabolism
MH  - Fruit/*chemistry
MH  - HL-60 Cells
MH  - Humans
MH  - Japan
MH  - Limonene
MH  - Medicine, East Asian Traditional
MH  - NF-kappa B/metabolism
MH  - Oils, Volatile/*chemistry
MH  - Phosphorylation/drug effects
MH  - Reactive Oxygen Species/metabolism
MH  - Terpenes/*pharmacology
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2010/05/25 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - JFDS1541 [pii]
AID - 10.1111/j.1750-3841.2010.01541.x [doi]
PST - ppublish
SO  - J Food Sci. 2010 Apr;75(3):H87-92. doi: 10.1111/j.1750-3841.2010.01541.x.