PMID- 20492592
OWN - NLM
STAT- MEDLINE
DCOM- 20101203
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 3
DP  - 2010 Sep
TI  - The association and differentiation of MHC class I polymorphic Alu insertions and 
      HLA-B/Cw alleles in seven Chinese populations.
PG  - 194-207
LID - 10.1111/j.1399-0039.2010.01499.x [doi]
AB  - We investigated polymorphic Alu insertion (POALIN) frequencies at five loci in 
      the major histocompatibility complex (MHC) class I genomic region to determine 
      their allele and haplotype frequencies and associations with the human leukocyte 
      antigen (HLA)-B and -Cw genes in seven different Chinese ethnic populations, the 
      Han, Bulang, Wa, Dai, Maonan, Hani and Jinuo. The POALINs varied in frequency 
      between 0% and 42.3% with significant differences between populations at all of 
      the loci. Each POALIN was in significant linkage disequilibrium with a variety of 
      HLA-B or -Cw four-digit alleles. The percentage association between Alu 
      insertions and the HLA-B or -Cw alleles was calculated in pairwise analyses of 
      haplotypes to show possible crossing over events between loci. The POALIN 
      insertions also helped to further stratify the HLA-B:-Cw haplotypes into 
      different POALIN:HLA-B:HLA-Cw haplotype frequencies. Of the two-locus, five-locus 
      and seven-locus haplotype analyses, the seven-locus haplotypes showed the largest 
      number of differences between the populations. The most common multilocus 
      haplotype in Han was MICB*1:B*4601:Cw*0102:TF*1:HJ*1:HG*2:HF*1 (15.6%) associated 
      with the AluHG insertion, whereas the second most common multilocus haplotype in 
      Han was MICB*1:B*1502:Cw*0801:TF*1:HJ*2:HG*1:HF*1 (11.8%) associated with the 
      AluHJ insertion. This comparative study of multilocus POALINs in the HLA class I 
      region of seven Chinese ethnic populations shows that POALINs alone or together 
      with the HLA class I alleles are informative genetic markers for the 
      identification of HLA class I allele and haplotype lineages and variations such 
      as crossing over events within the same and/or different populations.
FAU - Yao, Y
AU  - Yao Y
AD  - Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Kunming, China.
FAU - Shi, L
AU  - Shi L
FAU - Shi, L
AU  - Shi L
FAU - Kulski, J K
AU  - Kulski JK
FAU - Chen, J
AU  - Chen J
FAU - Liu, S
AU  - Liu S
FAU - Yu, L
AU  - Yu L
FAU - Lin, K
AU  - Lin K
FAU - Huang, X
AU  - Huang X
FAU - Tao, Y
AU  - Tao Y
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Chu, J
AU  - Chu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Alu Elements/*genetics
MH  - Asian People/*genetics
MH  - Ethnicity/genetics
MH  - *Genetics, Population
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Phylogeny
MH  - Polymorphism, Genetic/*genetics
EDAT- 2010/05/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - TAN1499 [pii]
AID - 10.1111/j.1399-0039.2010.01499.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Sep;76(3):194-207. doi: 10.1111/j.1399-0039.2010.01499.x.