PMID- 20492596
OWN - NLM
STAT- MEDLINE
DCOM- 20101203
LR  - 20100810
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 3
DP  - 2010 Sep
TI  - Distribution of KIR genes in the population of unrelated individuals homozygous 
      for ancestral haplotype AH8.1 (HLA-A1B8DR3).
PG  - 240-4
LID - 10.1111/j.1399-0039.2010.01504.x [doi]
AB  - Despite the independent segregation of genes encoding killer immunoglobulin-like 
      receptor (KIR) and human leukocyte antigen (HLA), there is some evidence of some 
      kind of co-evolution. Therefore, one could expect reduced KIR diversity within 
      the HLA restricted population. A total of 41 unrelated individuals homozygous for 
      ancestral HLA haplotype AH8.1 (HLA-A*0101-Cw*0701-B*0801-DRB1*0301-DQB1*0201) 
      were genotyped for KIRs. Over all, 14 different genotypes were identified. The 
      KIR genes and genotypes repertoire generally mirror the published frequencies in 
      Caucasians. Except for KIR2DS4, all activating genes presented frequencies below 
      50%. KIR2DS5 was the least frequent among activating genes (17%), whereas KIR2DL5 
      (37%) among inhibitory ones. The most frequent (39%) was AA genotype. Twenty-two 
      individuals (54%) had a copy of KIR haplotypes A and B (AB genotype), whereas 
      three (7%) were homozygous for B (BB genotype). Nine of fourteen reported 
      genotypes occurred only in one individual. Five genotypes were reported in less 
      than twenty individuals worldwide and one genotype was reported so far only once. 
      Conversely, the three most frequent genotypes account for 68% of all detected 
      genotypes. The results show the unrestricted KIR diversity in this HLA uniform 
      group and support the fact that the driving force for KIR evolution is not 
      exclusively a major histocompatibility complex.
FAU - Jindra, P
AU  - Jindra P
AD  - Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czech 
      Republic.
FAU - Venigova, P
AU  - Venigova P
FAU - Lysak, D
AU  - Lysak D
FAU - Steinerova, K
AU  - Steinerova K
FAU - Koza, V
AU  - Koza V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, KIR)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/analysis/genetics
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Haplotypes/*genetics
MH  - Homozygote
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Population Groups/*genetics
MH  - Receptors, KIR/*genetics
EDAT- 2010/05/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - TAN1504 [pii]
AID - 10.1111/j.1399-0039.2010.01504.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Sep;76(3):240-4. doi: 10.1111/j.1399-0039.2010.01504.x.