PMID- 20493227
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 8
DP  - 2010 Aug
TI  - Distributions of human leukocyte antigen-A, -B, and -DRB1 alleles and haplotypes 
      based on 46,915 Taiwanese donors.
PG  - 777-82
LID - 10.1016/j.humimm.2010.05.013 [doi]
AB  - Human leukocyte antigen (HLA)-A, -B, and -DRB1 alleles were typed in 46,915 
      healthy Taiwanese volunteers recruited for Tzu Chi Taiwan Marrow Donor Registry 
      (TCTMDR). The volunteers were separated into Taiwanese and Taiwanese aborigines. 
      In this study, a total of 51 A, 121 B, and 53 DRB1 alleles were found in the 
      Taiwanese group, and 17 A, 32 B, and 23 DRB1 alleles were identified in the 
      Taiwanese aborigines. Some commonly shared alleles appeared more frequently in 
      one group than in the other. The two haplotypes, among the 20 most frequently 
      observed haplotypes in each group, shared in common by both groups were 
      A*3303-B*5801-DRB1*0301 and A*0207-B*4601-DRB1* 0901. However, both haplotype 
      frequencies in each group were extremely different, indicating the existence of 
      genetic diversity between the two groups. In addition, principal component 
      analysis and clustering results based on high-resolution HLA-A, -B, and -DRB1 
      alleles indicated that the Taiwanese group was closest to Southern Chinese and 
      reiterated HLA diversity between the Taiwanese and the Taiwanese aborigines. We 
      believe that our findings in this study may provide useful information in search 
      for HLA-matched donors for patients.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Lai, Meng-Jiun
AU  - Lai MJ
AD  - Department of Laboratory of Medicine and Biotechnology, College of Medicine, 
      Buddhist Tzu-Chi University, Hualien, Taiwan.
FAU - Wen, Shu-Hui
AU  - Wen SH
FAU - Lin, Ya-Hui
AU  - Lin YH
FAU - Shyr, Ming-Huang
AU  - Shyr MH
FAU - Lin, Py-Yu
AU  - Lin PY
FAU - Yang, Kuo-Liang
AU  - Yang KL
LA  - eng
PT  - Journal Article
DEP - 20100520
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Bone Marrow/immunology
MH  - Cluster Analysis
MH  - Gene Frequency
MH  - Genetic Variation
MH  - HLA-A Antigens/classification/*genetics
MH  - HLA-B Antigens/classification/*genetics
MH  - HLA-DR Antigens/classification/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Principal Component Analysis
MH  - Registries
MH  - Taiwan
MH  - *Tissue Donors
EDAT- 2010/05/25 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/02/09 00:00 [received]
PHST- 2010/05/04 00:00 [revised]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - S0198-8859(10)00124-2 [pii]
AID - 10.1016/j.humimm.2010.05.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Aug;71(8):777-82. doi: 10.1016/j.humimm.2010.05.013. Epub 2010 
      May 20.