PMID- 20493567
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20151119
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 150
IP  - 3
DP  - 2011 Aug 4
TI  - The prognostic value of circulating markers of collagen turnover after acute 
      myocardial infarction.
PG  - 277-82
LID - 10.1016/j.ijcard.2010.04.034 [doi]
AB  - BACKGROUND: We assessed the time profiles and prognostic utility of circulating 
      markers of collagen turnover (CTO) following acute myocardial infarction (MI). In 
      contrast to previous studies, no patient had been pre-treated with inhibitors of 
      the renin-angiotensin-aldosterone system (RAAS) at the time of initial 
      assessment. METHODS: Plasma levels of N-terminal fragment of type I collagen 
      (PINP), carboxy-terminal telopeptide of type I collagen (ICTP), N-terminal 
      fragment of type III collagen (PIIINP), matrix metalloproteinase-1(MMP-1) and 
      tissue inhibitor of MMPs type-1 (TIMP-1) were assessed in 233 patients following 
      acute MI. The CTO markers were initially assessed prior to treatment by either 
      captopril or losartan, at a median of 3 days following MI. In addition, blood 
      samples were acquired at 1 month, 1 year and 2 years following MI. Development of 
      heart failure symptoms, all-cause and cardiovascular death were recorded as 
      endpoints during two years of follow-up. RESULTS: With the exception of PIIINP, 
      all CTO markers demonstrated significant longitudinal changes following MI. At 
      baseline, ICTP (p<0.0001) and TIMP-1 (p=0.01) levels were significantly elevated 
      in patients who later died compared with survivors. In multivariable analysis 
      only ICTP reached statistical significance as predictor of all cause death 
      (p=0.048). In patients developing symptoms of heart failure during follow-up, 
      ICTP was the only significantly elevated CTO marker (p<0.01). CONCLUSION: The 
      present study supports a prognostic role for ICTP in both the acute and chronic 
      phase following MI.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Manhenke, Cord
AU  - Manhenke C
AD  - Stavanger University Hospital, Stavanger, Norway. maco@sus.no
FAU - Orn, Stein
AU  - Orn S
FAU - Squire, Iain
AU  - Squire I
FAU - Radauceanu, Anca
AU  - Radauceanu A
FAU - Alla, Francois
AU  - Alla F
FAU - Zannad, Faiez
AU  - Zannad F
FAU - Dickstein, Kenneth
AU  - Dickstein K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100520
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Collagen Type I/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/*diagnosis/mortality
MH  - Prognosis
MH  - Prospective Studies
MH  - Time Factors
EDAT- 2010/05/25 06:00
MHDA- 2012/06/01 06:00
CRDT- 2010/05/25 06:00
PHST- 2009/05/11 00:00 [received]
PHST- 2010/03/30 00:00 [revised]
PHST- 2010/04/10 00:00 [accepted]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S0167-5273(10)00250-0 [pii]
AID - 10.1016/j.ijcard.2010.04.034 [doi]
PST - ppublish
SO  - Int J Cardiol. 2011 Aug 4;150(3):277-82. doi: 10.1016/j.ijcard.2010.04.034. Epub 
      2010 May 20.