PMID- 20495297
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20190902
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 56
IP  - 2
DP  - 2010
TI  - Immunomodulatory effect of Eriobotrya japonica seed extract on allergic 
      dermatitis rats.
PG  - 145-9
AB  - We examined the immunomodulatory effect of Eriobotrya japonica seed extract (ESE) 
      on rat allergic dermatitis elicited by repeated dinitrofluorobenzene (DNFB) 
      application on the ear. Oral administration of ESE significantly inhibited 
      development of allergic dermatitis based on lower ear thickness and serum 
      immunoglobulin E (IgE) levels. Th1 cytokine interferon-gamma (IFN-gamma) and 
      interleukin-2 (IL-2), Th2 cytokine interleukin-4 (IL-4) and interleukin-10 
      (IL-10) in the lesional skin were determined. Oral administration of ESE 
      significantly decreased IL-4 while significantly increasing IL-10 in lesional 
      skin, and the lower levels of IFN-gamma and IL-2 were reversed by oral 
      administration of ESE. The infiltration of eosinophils in the lesional skin was 
      decreased by oral administration of ESE. These results suggested that ESE exerts 
      anti-allergic actions by improving the balance of Th1/Th2 in allergic dermatitis.
FAU - Sun, Guangchen
AU  - Sun G
AD  - School of Pharmacy Sciences, Jiamusi University, Jiamusi City, Heilongjiang, 
      China.
FAU - Liu, Yingqin
AU  - Liu Y
FAU - Zhu, Jinling
AU  - Zhu J
FAU - Iguchi, Miki
AU  - Iguchi M
FAU - Yoshioka, Saburo
AU  - Yoshioka S
FAU - Miyamura, Mitsuhiko
AU  - Miyamura M
FAU - Kyotani, Shojiro
AU  - Kyotani S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Cytokines)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Oral
MH  - Analysis of Variance
MH  - Animals
MH  - Cytokines/blood/drug effects
MH  - Dermatitis, Allergic Contact/blood/complications/*prevention & control
MH  - Disease Models, Animal
MH  - Ear
MH  - Edema/etiology/prevention & control
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - *Eriobotrya
MH  - Immunoglobulin E/blood
MH  - Immunosuppressive Agents/blood/*pharmacology
MH  - Male
MH  - Plant Extracts/blood/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Seeds
EDAT- 2010/05/25 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - JST.JSTAGE/jnsv/56.145 [pii]
AID - 10.3177/jnsv.56.145 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2010;56(2):145-9. doi: 10.3177/jnsv.56.145.