PMID- 20495681
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1875-6506 (Electronic)
IS  - 1573-4021 (Print)
IS  - 1573-4021 (Linking)
VI  - 5
IP  - 2
DP  - 2009 May 1
TI  - Hyperhomocysteinemia and Endothelial Dysfunction.
PG  - 158-165
AB  - Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for 
      cardiovascular diseases. Endothelial dysfunction (ED) is the earliest indicator 
      of atherosclerosis and vascular diseases. We and others have shown that HHcy 
      induced ED in human and in animal models of HHcy induced by either 
      high-methionine load or genetic deficiency. Six mechanisms have been suggested 
      explaining HHcy-induced ED. These include 1) nitric oxide inhibition, 2) 
      prostanoids regulation, 3) endothelium-derived hyperpolarizing factors 
      suppression, 4) angiotensin II receptor-1 activation, 5) endothelin-1 induction, 
      and 6) oxidative stress. The goal of this review is to elaborate these mechanisms 
      and to discuss biological and molecular events related to HHcy-induced ED.
FAU - Cheng, Zhongjian
AU  - Cheng Z
AD  - Department of Pharmacology, Temple University School of Medicine, Philadelphia, 
      PA, USA.
FAU - Yang, Xiaofeng
AU  - Yang X
FAU - Wang, Hong
AU  - Wang H
LA  - eng
GR  - R01 HL077288-06/HL/NHLBI NIH HHS/United States
GR  - R01 HL077288/HL/NHLBI NIH HHS/United States
GR  - R01 HL117654/HL/NHLBI NIH HHS/United States
GR  - R01 HL082774/HL/NHLBI NIH HHS/United States
GR  - R01 HL067033-08/HL/NHLBI NIH HHS/United States
GR  - R01 HL082774-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL067033/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Hypertens Rev
JT  - Current hypertension reviews
JID - 101239891
PMC - PMC2873778
MID - NIHMS198207
EDAT- 2010/05/25 06:00
MHDA- 2010/05/25 06:01
PMCR- 2010/05/20
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/05/25 06:01 [medline]
PHST- 2010/05/20 00:00 [pmc-release]
AID - 10.2174/157340209788166940 [doi]
PST - ppublish
SO  - Curr Hypertens Rev. 2009 May 1;5(2):158-165. doi: 10.2174/157340209788166940.