PMID- 20495831
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20211020
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 25
IP  - 9
DP  - 2010 Sep
TI  - Beneficial effect of cinacalcet in a child with familial hypocalciuric 
      hypercalcemia.
PG  - 1747-50
LID - 10.1007/s00467-010-1547-5 [doi]
AB  - We describe a child with familial hypocalciuric hypercalcemia (FHH) in whom the 
      hypercalcemia seemed to interfere with tissue healing after tympanoplasty. 
      Consequently, he was placed on cinacalcet (30 mg/day), changed after 2 weeks to 
      60 mg/day. The treatment resulted in a decrease in serum parathyroid hormone 
      (PTH) from 148 to 32 pg/mL (normal 7-75) and ionized calcium from 1.48 to 1.23 
      mmol/L (1.13-1.34), as well as successful healing of the revised surgical scar. 
      Over the 12-month treatment period no complications were noted. We conclude that 
      cinacalcet may be considered a new, and currently the only, tool in treating 
      children with symptomatic FHH.
FAU - Alon, Uri S
AU  - Alon US
AD  - Section of Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children's 
      Mercy Hospitals and Clinics, University of Missouri at Kansas City, 2401 Gillham 
      Road, Kansas City, MI 64108, USA. ualon@cmh.edu
FAU - VandeVoorde, Rene G
AU  - VandeVoorde RG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100522
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Biomarkers)
RN  - 0 (CASR protein, human)
RN  - 0 (Naphthalenes)
RN  - 0 (PTH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Receptors, Calcium-Sensing)
RN  - SY7Q814VUP (Calcium)
RN  - UAZ6V7728S (Cinacalcet)
SB  - IM
MH  - Biomarkers/blood/urine
MH  - *Calcium/blood/urine
MH  - Child
MH  - Cinacalcet
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypercalcemia/blood/*drug therapy/genetics/urine
MH  - Male
MH  - Mutation
MH  - Naphthalenes/*therapeutic use
MH  - Parathyroid Hormone/blood
MH  - Pedigree
MH  - Receptors, Calcium-Sensing/genetics
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tympanoplasty
MH  - Wound Healing/drug effects
EDAT- 2010/05/25 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/05/25 06:00
PHST- 2009/11/02 00:00 [received]
PHST- 2010/04/06 00:00 [accepted]
PHST- 2010/04/01 00:00 [revised]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1007/s00467-010-1547-5 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2010 Sep;25(9):1747-50. doi: 10.1007/s00467-010-1547-5. Epub 
      2010 May 22.