PMID- 20496196
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20171116
IS  - 1477-2213 (Electronic)
IS  - 1028-6020 (Linking)
VI  - 12
IP  - 5
DP  - 2010 May
TI  - Effects of bicyclol on immunological liver fibrosis in rats.
PG  - 388-98
LID - 10.1080/10286021003789047 [doi]
AB  - Liver fibrosis results from chronic liver injury in conjunction with the 
      accumulation of extracellular matrix proteins. The present study was performed to 
      estimate the effect of bicyclol on bovine serum albumin (BSA)-induced 
      immunological liver fibrosis in rats. Bicyclol (1) (100, 200, and 300 mg/kg) was 
      given to rats by oral administration once a day for 5 weeks from the fourth week 
      of intravenous injection of BSA. Blood and liver tissues were collected for the 
      measurement of hydroxyproline (Hyp), procollagen type III (PIIIP), hyaluronic 
      acid (HA), and transforming growth factor beta-1 (TGF-beta1) levels and liver 
      pathological changes. The mRNA and protein expressions of hepatic TGF-beta1, 
      interleukin-1 (IL-1), IL-10, MMP-2, TIMP-1, phosphorylated p38 (Pp38), and 
      Smad2/3 were detected by reverse transcription polymerase chain reaction and 
      Western blot. As a result, bicyclol significantly protected against BSA-induced 
      liver fibrosis as evidenced by the reduction of elevated serum HA, PIIIP, and 
      hepatic Hyp in rats, while liver pathological changes were also alleviated. The 
      overexpressions of hepatic TGF-beta1, IL-1beta, IL-10, MMP-2, and TIMP-1 were 
      suppressed by bicyclol in BSA-treated rats. The phosphorylations of Pp38 and 
      Smad2/3 were also inhibited after bicyclol treatment. The hepatoprotection of 
      bicyclol was mainly due to the modulation on the expression of 
      inflammatory/anti-inflammatory cytokines, downregulation of hepatic TGF-beta1, 
      and inhibition of hepatic collagen synthesis.
FAU - Gu, Yu
AU  - Gu Y
AD  - The Institute of Medicinal Plant Development, Peking Union Medical College and 
      Chinese Academy of Medical Sciences, Beijing, China.
FAU - Zhao, Jing
AU  - Zhao J
FAU - Yao, Xiao-Min
AU  - Yao XM
FAU - Li, Yan
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asian Nat Prod Res
JT  - Journal of Asian natural products research
JID - 100888334
RN  - 0 (Biphenyl Compounds)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 9734122TH2 (bicyclol)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Alanine Transaminase/analysis
MH  - Animals
MH  - Aspartate Aminotransferases/analysis
MH  - Biphenyl Compounds/chemistry/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Liver/*drug effects
MH  - *Liver Cirrhosis/chemically induced/metabolism/pathology
MH  - Male
MH  - Matrix Metalloproteinase 2/drug effects
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sequence Homology, Nucleic Acid
MH  - Serum Albumin, Bovine/*pharmacology
MH  - Tissue Inhibitor of Metalloproteinases/drug effects
MH  - Transforming Growth Factor beta1/drug effects/metabolism
EDAT- 2010/05/25 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 922439587 [pii]
AID - 10.1080/10286021003789047 [doi]
PST - ppublish
SO  - J Asian Nat Prod Res. 2010 May;12(5):388-98. doi: 10.1080/10286021003789047.