PMID- 20497022
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20221207
IS  - 1521-0499 (Electronic)
IS  - 0190-2148 (Linking)
VI  - 36
IP  - 5
DP  - 2010 Jun
TI  - MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese 
      men.
PG  - 277-83
LID - 10.3109/01902140903575989 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) plays a major role in the recruitment 
      of inflammatory cells to the lungs of patients with chronic obstructive pulmonary 
      disease (COPD). However, the influence of MCP1 gene polymorphism on COPD 
      development has not been studied. This study aimed to investigate the association 
      between MCP1 -2518 polymorphisms and COPD and between this polymorphism and 
      plasma MCP-1 levels. The plasma MCP-1 was measured by using an enzyme-linked 
      immunosorbent assay and polymorphisms detection was performed by denaturing 
      high-performance liquid chromatography. COPD group had higher plasma MCP1 levels 
      than healthy participants (257.0 versus 194.4 pg/mL) in the univariate analysis 
      (P = .005); and in stepwise liner regression analysis after adjustment for age, 
      alcohol, body mass index, cancer history, and steroid use (P = .002; 95% 
      confidence interval [CI]: 30.72-128.02). Plasma MCP-1 was negatively correlated 
      with forced expiratory volume in one second (FEV(1)%) (P = .003; r = -.274). 
      SNPStats including codominant, dominant, recessive, overdominant, and 
      log-additive model analysis showed MCP1 -2518 polymorphisms had no association 
      with the risk of COPD. Generalized linear model showed no association between 
      plasma MCP-1 levels and MCP1 -2518 genotypes. In conclusion, there is no 
      association between MCP1 -2518 gene polymorphisms and COPD or between this gene 
      polymorphisms and plasma MCP-1 levels in the Taiwanese men.
FAU - Liu, Shih-Feng
AU  - Liu SF
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung 
      University College of Medicine, Kaohsiung Hsien, Taiwan, ROC.
FAU - Wang, Chin-Chou
AU  - Wang CC
FAU - Fang, Wen-Feng
AU  - Fang WF
FAU - Chen, Yung-Che
AU  - Chen YC
FAU - Lin, Meng-Chih
AU  - Lin MC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Asian People/*genetics
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - Chi-Square Distribution
MH  - Chromatography, High Pressure Liquid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Forced Expiratory Volume
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - *Men's Health
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic 
      Obstructive/ethnology/*genetics/immunology/physiopathology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Smoking/ethnology
MH  - Taiwan
MH  - Vital Capacity
EDAT- 2010/05/26 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 10.3109/01902140903575989 [doi]
PST - ppublish
SO  - Exp Lung Res. 2010 Jun;36(5):277-83. doi: 10.3109/01902140903575989.