PMID- 20497453
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20101223
IS  - 1469-8749 (Electronic)
IS  - 0012-1622 (Linking)
VI  - 52
IP  - 11
DP  - 2010 Nov
TI  - The effect of gastrostomy tube feeding on body protein and bone mineralization in 
      children with quadriplegic cerebral palsy.
PG  - 1043-7
LID - 10.1111/j.1469-8749.2010.03702.x [doi]
AB  - AIM: The aim of this study was to investigate the effect of gastrostomy tube 
      feeding on body protein and bone mineralization in malnourished children with 
      cerebral palsy (CP). METHOD: Children aged between 4 and 18 years with spastic 
      quadriplegic CP (Gross Motor Function Classification System level V) were 
      recruited from the Children's Hospital at Westmead to participate in this 
      prospective cohort study. The children had measurements of anthropometry (weight, 
      height, and skinfold), bone mineral content (BMC) by dual-energy X-ray 
      absorptiometry, and total body protein (TBP) by neutron activation analysis 
      before and after gastrostomy tube feeding. Comparison data were collected 
      prospectively from age-matched healthy children and extracted from databases for 
      this study. RESULTS: A total of 21 children (nine females, 12 males) participated 
      in the study (median age 8 y 5 mo; interquartile range [IQR] 6 y 9 mo-11 y 10 
      mo). The median length of time of gastrostomy feeding was 19.4 months (IQR 
      7.7-29.9 mo). Significant (p<0.05) improvements were found in the median values 
      for weight (15.4-23.3 kg), weight standard deviation scores (SDS; -4.8 to -3.0), 
      height (105.4-118.3 cm), per cent body fat (10.7-16.3), TBP (2.4-3.4 kg), TBP per 
      cent predicted for height (83.4-99.0), and BMC (469-626 g). No significant 
      increases were found in height SDS, TBP per cent predicted for age, or BMC SDS 
      for age or height. INTERPRETATION: Malnourished children with quadriplegic CP 
      showed significant increases in body fat and protein with gastrostomy tube 
      feeding. No significant change in bone mineralization predicted for age or height 
      was observed.
CI  - (c) The Authors. Journal compilation (c) Mac Keith Press 2010.
FAU - Arrowsmith, Fiona
AU  - Arrowsmith F
AD  - Department of Gastroenterology, The Children's Hospital at Westmead, New South 
      Wales, Australia.
FAU - Allen, Jane
AU  - Allen J
FAU - Gaskin, Kevin
AU  - Gaskin K
FAU - Somerville, Helen
AU  - Somerville H
FAU - Clarke, Samantha
AU  - Clarke S
FAU - O'Loughlin, Edward
AU  - O'Loughlin E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
SB  - IM
CIN - Dev Med Child Neurol. 2010 Nov;52(11):985. PMID: 20561012
MH  - Absorptiometry, Photon
MH  - *Body Composition
MH  - Body Weight
MH  - Bone Density
MH  - *Cerebral Palsy/complications/metabolism/therapy
MH  - Child
MH  - Child, Preschool
MH  - *Enteral Nutrition
MH  - Female
MH  - Follow-Up Studies
MH  - *Gastrostomy
MH  - Humans
MH  - Male
MH  - *Quadriplegia/complications/metabolism/therapy
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/05/26 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - DMCN3702 [pii]
AID - 10.1111/j.1469-8749.2010.03702.x [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2010 Nov;52(11):1043-7. doi: 
      10.1111/j.1469-8749.2010.03702.x.