PMID- 20497645
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100525
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 12
IP  - 5
DP  - 2010 May
TI  - [Physical training improves spatial learning and memory impairments following 
      hypoxic ischemic brain damage in neonatal rats].
PG  - 363-7
AB  - OBJECTIVE: To investigate the effect of physical training on cerebral structure 
      and spatial learning and memory in neonatal rats submitted to hypoxic-ischemic 
      brain damage (HIBD). METHODS: Forty-eight 7-day-old Sprague-Dawley rats were 
      randomly divided into three groups: a group that was subjected to left carotid 
      ligation followed by 2 hrs hypoxic stress (HIBD); a group that received physical 
      training 2 weeks after the HIBD event; a control group that was subjected to a 
      sham-operation without ligation and hypoxic stress. Following four weeks physical 
      training, motor function test and water maze tasks were performed. Bilateral 
      brain weight, cerebral morphology and left hippocampal ultrastructrue of the 
      animals were examined. The expression levels of phosphor calmodulin-dependent 
      protein kinase II (CaMKII) and brain derived neurotrophic factor (BDNF) were 
      determined by immunohistochemistry. RESULTS: Compared with the control group, the 
      motor function and the spatial learning and memory ability in the non-trained 
      HIBD group were significantly decreased, whereas there was no significant 
      difference between the trained-HIBD and the control groups. The left hemisphere 
      weight and neurons in the left hippocampal CA1 zone of both HIBD groups decreased 
      and the reduction was more significant in non-trained HIBD group. The 
      ultrastructure of the left hippocampus was remarkably abnormal in the non-trained 
      HIBD group, while no obvious abnormality was observed in the trained HIBD and the 
      control groups. Phosphor-CaMKII and BDNF expression in the left hippocampus in 
      the trained HIBD group increased significantly compared with that in the 
      non-trained HIBD group. CONCLUSIONS: Physical training can restrain brain damage 
      and ameliorate spatial learning and memory impairments in rats with HIBD.
FAU - Chen, Xiao-Lu
AU  - Chen XL
AD  - Department of Neurology, Children's Hospital of Chongqing Medical University, 
      Chongqing, China.
FAU - Jiang, Li
AU  - Jiang L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism
MH  - Hypothalamus/metabolism/ultrastructure
MH  - Hypoxia-Ischemia, Brain/pathology/physiopathology/*psychology/therapy
MH  - *Maze Learning
MH  - *Memory
MH  - Phosphorylation
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/05/26 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 1008-8830(2010)05-0363-05 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2010 May;12(5):363-7.