PMID- 20500661
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20181201
IS  - 1365-3024 (Electronic)
IS  - 0141-9838 (Linking)
VI  - 32
IP  - 5
DP  - 2010 May
TI  - Distinct host-related dendritic cell responses during the early stage of 
      Plasmodium yoelii infection in susceptible and resistant mice.
PG  - 324-34
LID - 10.1111/j.1365-3024.2009.01190.x [doi]
AB  - The diverse outcomes of experimental murine infection with Plasmodium parasites, 
      ranging from spontaneous cure to death, depend largely on the establishment of an 
      effective Th1 immune response during the early stages of infection. However, the 
      molecular and cellular factors responsible for the induction and regulation of 
      this response are poorly understood. As immunity is initiated by dendritic cells 
      (DCs), we compared their phenotype and function during the early stages of 
      infection with Plasmodium yoelii 17XL (P.y 17XL) strain in susceptible (BALB/c) 
      and resistant (DBA/2) mice. Resistant DBA/2 mice developed a greater number of 
      myeloid (CD11c(+)CD11b(+)) and mature DCs, which were fully functional and 
      capable of secreting IL-12p40. In contrast, susceptible BALB/c mice produced more 
      plasmacytoid (CD11c(+)CD45R/B220(+)) and less mature DCs, resulting in high 
      levels of IL-10 and TGF-beta1. In addition, an in vitro experiment confirmed that 
      splenic DCs from the two strains of mice differ in their ability to prime CD4(+)T 
      cells in response to P.y 17XL stimulation. These findings indicate that the 
      subset, the phenotype and the type of inflammatory and anti-inflammatory signals 
      of splenic DCs are critical factors responsible for the discrepancy in the 
      ability to induce or regulate Th1 immune responses in different hosts.
FAU - Zheng, W
AU  - Zheng W
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang, China.
FAU - Wang, Q-H
AU  - Wang QH
FAU - Liu, Y-J
AU  - Liu YJ
FAU - Liu, J
AU  - Liu J
FAU - Feng, H
AU  - Feng H
FAU - Wu, J-J
AU  - Wu JJ
FAU - Cao, Y-M
AU  - Cao YM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Parasite Immunol
JT  - Parasite immunology
JID - 7910948
RN  - 0 (Antigens, CD)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Antigens, CD/analysis
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Dendritic Cells/chemistry/*immunology
MH  - Female
MH  - Interleukin-10/metabolism
MH  - Interleukin-12 Subunit p40/metabolism
MH  - Malaria/*immunology/parasitology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred DBA
MH  - Plasmodium yoelii/*immunology
MH  - Transforming Growth Factor beta1/metabolism
EDAT- 2010/05/27 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - PIM1190 [pii]
AID - 10.1111/j.1365-3024.2009.01190.x [doi]
PST - ppublish
SO  - Parasite Immunol. 2010 May;32(5):324-34. doi: 10.1111/j.1365-3024.2009.01190.x.