PMID- 20501670
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20230919
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 151
IP  - 8
DP  - 2010 Aug
TI  - Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate 
      nucleus: a central node in the control of gonadotropin-releasing hormone 
      secretion.
PG  - 3479-89
LID - 10.1210/en.2010-0022 [doi]
AB  - Recently, a subset of neurons was identified in the arcuate nucleus of the 
      hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and 
      dynorphin, each of which has been shown to play a critical role in the central 
      control of reproduction. Growing evidence suggests that these neurons, 
      abbreviated as the KNDy subpopulation, are strongly conserved across a range of 
      species from rodents to humans and play a key role in the physiological 
      regulation of GnRH neurons. KNDy cells are a major target for steroid hormones, 
      form a reciprocally interconnected network, and have direct projections to GnRH 
      cell bodies and terminals, features that position them well to convey steroid 
      feedback control to GnRH neurons and potentially serve as a component of the GnRH 
      pulse generator. In addition, recent work suggests that alterations in KNDy cell 
      peptides may underlie neuroendocrine defects seen in clinical reproductive 
      disorders such as polycystic ovarian syndrome. Taken together, this evidence 
      suggests a key role for the KNDy subpopulation as a focal point in the control of 
      reproductive function in health and disease.
FAU - Lehman, Michael N
AU  - Lehman MN
AD  - Department of Anatomy and Cell Biology, Medical Sciences Building, University of 
      Western Ontario, London, Ontario, Canada. michael.lehman@schulich.uwo.ca
FAU - Coolen, Lique M
AU  - Coolen LM
FAU - Goodman, Robert L
AU  - Goodman RL
LA  - eng
GR  - 86744/CAPMC/CIHR/Canada
GR  - P01 HD44232/HD/NICHD NIH HHS/United States
GR  - R01 HD39916/HD/NICHD NIH HHS/United States
GR  - P01 HD044232/HD/NICHD NIH HHS/United States
GR  - R01 HD039916/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100525
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (KISS1 protein, human)
RN  - 0 (Kisspeptins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 74913-18-1 (Dynorphins)
RN  - 86933-75-7 (Neurokinin B)
SB  - IM
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/cytology/*metabolism/*physiology
MH  - Dynorphins/*metabolism
MH  - Feedback, Physiological/drug effects/physiology
MH  - Gonadal Steroid Hormones/pharmacology
MH  - Gonadotropin-Releasing Hormone/*metabolism
MH  - Humans
MH  - Kisspeptins
MH  - Models, Biological
MH  - Neurokinin B/*metabolism
MH  - Periodicity
MH  - Tumor Suppressor Proteins/*metabolism
PMC - PMC2940527
EDAT- 2010/05/27 06:00
MHDA- 2010/09/09 06:00
PMCR- 2011/08/01
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - en.2010-0022 [pii]
AID - 5470 [pii]
AID - 10.1210/en.2010-0022 [doi]
PST - ppublish
SO  - Endocrinology. 2010 Aug;151(8):3479-89. doi: 10.1210/en.2010-0022. Epub 2010 May 
      25.