PMID- 20503485
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20211203
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Apr
TI  - The potential role of mTOR inhibitors in the treatment of endocrine tumors.
PG  - 276-81
AB  - Mammalian target of rapamycin (mTOR), a main protein kinase in the 
      phosphoinositide 3-kinase/Akt/p70S6K signaling pathway, is an important 
      intracellular mediator involved in multiple cellular functions including 
      proliferation, differentiation, apoptosis, longevity, tumorigenesis, and 
      angiogenesis. Alterations of the normal activity of mTOR and of mTOR-related 
      kinases in this pathway have been found in a diversity of human tumors, 
      suggesting that mTOR may be an attractive target for the development of new 
      anti-cancer therapies. The main objective of this article is to summarize the 
      available pre-clinical and clinical data regarding a possible role of mTOR 
      inhibitors in the treatment of different endocrine cancers.
FAU - Grozinsky-Glasberg, S
AU  - Grozinsky-Glasberg S
AD  - Institute of Endocrinology and Felsenstein Research Center, Beilinson Hospital, 
      Rabin Medical Center, Petah Tiqva, Israel.
FAU - Shimon, I
AU  - Shimon I
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100505
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Animals
MH  - Endocrine Gland Neoplasms/*drug therapy/metabolism/pathology
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Protein Kinase Inhibitors/*therapeutic use
MH  - Protein Serine-Threonine Kinases/*antagonists & inhibitors
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Signal Transduction/physiology
MH  - TOR Serine-Threonine Kinases
MH  - ras Proteins/metabolism
EDAT- 2010/05/27 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 7056 [pii]
AID - 10.1007/BF03345792 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2010 Apr;33(4):276-81. doi: 10.1007/BF03345792. Epub 2010 
      May 5.