PMID- 20504652
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20190902
IS  - 0197-0186 (Print)
IS  - 0197-0186 (Linking)
VI  - 17
IP  - 4
DP  - 1990
TI  - 3,4-methylenedioxymethamphetamine (MDMA)-induced release of endogenous serotonin 
      from the rat dorsal raphe nucleus in vitro: Effects of fluoxetine and tryptophan.
PG  - 509-13
AB  - The serotonin releasing action of 3,4-methylenedioxymethamphetamine on slices of 
      dorsal raphe nucleus from rat was investigated. The slices were maintained in a 
      gas-liquid interface perfusion chamber used for electrophysiological recording. 
      Microdialysis probes designed for use on the slice surface were employed to 
      measure the release of endogenous serotonin which was determined using liquid 
      chromatography with electrochemical detection. Three minute duration exposure of 
      the slices to 100 micromolar 3,4-methylenedioxymethamphetamine caused a long 
      lasting release of endogenous serotonin. Fluoxetine, a serotonin transport 
      inhibitor, reduced the amount of serotonin release. Tryptophan added to the 
      perfusion solution increased both the duration and amount of serotonin released. 
      These results further support earlier work on the mechanism of 
      3,4-methylenedioxymethamphetamine induced inhibition of serotonin neuronal 
      firing.
FAU - Bradberry, C W
AU  - Bradberry CW
AD  - Departments of Pharmacology and Psychiatry, Yale University School of Medicine, 
      333 Cedar Street, New Haven, CT 06510, U.S.A.
FAU - Sprouse, J S
AU  - Sprouse JS
FAU - Aghajanian, G K
AU  - Aghajanian GK
FAU - Roth, R H
AU  - Roth RH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 2010/05/28 06:00
PHST- 1990/01/26 00:00 [received]
PHST- 1990/03/12 00:00 [accepted]
PHST- 2010/05/28 06:00 [entrez]
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
AID - 0197-0186(90)90037-T [pii]
AID - 10.1016/0197-0186(90)90037-t [doi]
PST - ppublish
SO  - Neurochem Int. 1990;17(4):509-13. doi: 10.1016/0197-0186(90)90037-t.