PMID- 20504833
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20100824
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 19
IP  - 10
DP  - 2010 Sep
TI  - Association between anti-beta2 glycoprotein I antibodies and renal glomerular C4d 
      deposition in lupus nephritis patients with glomerular microthrombosis: a 
      prospective study of 155 cases.
PG  - 1195-203
LID - 10.1177/0961203310368409 [doi]
AB  - Glomerular microthrombosis (GMT) is a common vascular change in patients with 
      lupus nephritis (LN). The mechanism underlying GMT is still unknown. In our 
      previous study, we found that the level of IgG anti-beta2 glycoprotein I 
      (beta2GPI) antibodies was higher in the LN-GMT group than in the LN-non-GMT 
      group, which indicated that anti-beta2GPI antibodies may play a role in GMT 
      formation. Many studies have demonstrated that the activation of the classical 
      complement pathway may play a critical role in fetal loss and aPL-induced 
      thrombosis formation. To investigate whether complement activation plays a role 
      in GMT formation and to evaluate its relationship with aPL, we prospectively 
      investigated deposition of C4d in 155 renal biopsy specimens of LN patients. The 
      results revealed a strong relationship between the intensity of glomerular C4d 
      staining and the presence of microthrombi (p < 0.001). The detection rate of IgG 
      anti-beta2GPI antibodies was higher in the LN-GMT group than in the LN-non-GMT 
      group (p < 0.05). Further, the intensity of glomerular C4d staining was 
      significantly related with IgG anti-beta2GPI antibodies (p < 0.05). The results 
      of our study suggest that anti-beta2GPI antibodies may play a role in GMT 
      formation, and this process might involve complement activation.
FAU - Shen, Y
AU  - Shen Y
AD  - Department of Rheumatology, Renji Hospital Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Chen, X-W
AU  - Chen XW
FAU - Sun, C-Y
AU  - Sun CY
FAU - Dai, M
AU  - Dai M
FAU - Yan, Y-C
AU  - Yan YC
FAU - Yang, C-D
AU  - Yang CD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Peptide Fragments)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 80295-50-7 (Complement C4b)
RN  - 80295-52-9 (complement C4d)
SB  - IM
MH  - Adult
MH  - Autoantibodies/immunology
MH  - Biopsy
MH  - Complement C4b/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - Kidney Glomerulus/immunology/pathology
MH  - Lupus Nephritis/*complications/immunology
MH  - Male
MH  - Middle Aged
MH  - Peptide Fragments/*metabolism
MH  - Prospective Studies
MH  - Thrombosis/etiology/immunology/*physiopathology
MH  - Young Adult
MH  - beta 2-Glycoprotein I/*immunology
EDAT- 2010/05/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 0961203310368409 [pii]
AID - 10.1177/0961203310368409 [doi]
PST - ppublish
SO  - Lupus. 2010 Sep;19(10):1195-203. doi: 10.1177/0961203310368409. Epub 2010 May 26.