PMID- 20505661
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Linking)
VI  - 3
IP  - 5
DP  - 2010 Sep
TI  - Progesterone regulation of uterine dendritic cell function in rodents is 
      dependent on the stage of estrous cycle.
PG  - 496-505
LID - 10.1038/mi.2010.28 [doi]
AB  - Steroid hormones, such as progesterone, are able to modify immunity and influence 
      disease outcome. Dendritic cells (DCs) drive potent immune responses, express 
      receptors for steroid hormones, and may be a primary target of steroid hormone 
      actions during infection of the genital tract, including uterine tissue. Here, we 
      report that progesterone limited DC-associated activation marker expression and 
      inhibited cytokine secretion by uterine DCs, which was associated with changes in 
      signal transducer and activator of transcription 1 (STAT1) activity. We also 
      found that DCs from mice at stages with higher progesterone concentrations 
      (diestrus, metaestrus) were more sensitive to progesterone than those in stages 
      with lower progesterone concentrations (proestrus, estrus), both in vitro and in 
      vivo. This difference correlated with the levels of progesterone receptor 
      expressed by DCs. These data suggest that progesterone regulates DC function and 
      could contribute to the susceptibility of females to uterine and other genital 
      tract infections at selected time periods throughout the life cycle.
FAU - Butts, C L
AU  - Butts CL
AD  - Section on Neuroendocrine Immunology & Behavior, National Institute of Mental 
      Health, Bethesda, Maryland, USA.
FAU - Candando, K M
AU  - Candando KM
FAU - Warfel, J
AU  - Warfel J
FAU - Belyavskaya, E
AU  - Belyavskaya E
FAU - D'Agnillo, F
AU  - D'Agnillo F
FAU - Sternberg, E M
AU  - Sternberg EM
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20100526
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (STAT1 Transcription Factor)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Administration, Intravaginal
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Cells, Cultured
MH  - Cytokines/*biosynthesis/genetics/immunology/metabolism
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Female
MH  - Lipopolysaccharides/immunology/metabolism
MH  - Menstrual Cycle/blood
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Progesterone/blood/immunology/*metabolism
MH  - Receptors, Progesterone/*biosynthesis/genetics/immunology
MH  - STAT1 Transcription Factor/genetics/immunology/*metabolism
MH  - Signal Transduction/physiology
MH  - Transcriptional Activation/physiology
MH  - Uterus/cytology
EDAT- 2010/05/28 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S1933-0219(22)01508-2 [pii]
AID - 10.1038/mi.2010.28 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2010 Sep;3(5):496-505. doi: 10.1038/mi.2010.28. Epub 2010 May 
      26.