PMID- 20507254
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20100616
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Jul
TI  - Toxicology mechanism of the persistent organic pollutants (POPs) in fish through 
      AhR pathway.
PG  - 279-86
LID - 10.3109/15376516.2010.485227 [doi]
AB  - With the development of industry and agriculture, the cases of cancer and tumor 
      have been increasing gradually in the last 30 years, and quite a few cases are 
      caused by persistent organic pollutants (POPs), some of them belonging to 
      environmental endocrine disruptors, and they have become ubiquitous in the 
      environment, especially in the aquatic ecosystem; so this issue has aroused the 
      extensive attention of the world. The mechanism of POPs toxicology is very 
      complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) 
      pathway in fish. In order to gain a comprehensive understanding of the AhR 
      pathway, the present paper focuses on reviewing it from four major steps, 
      including formation of cytosolic complex, translocation of AhR, 
      heterodimerization of AhR, and induction of CYP1A. This study summarized the 
      isoform numbers of AhR pathway genes and the expression patterns in the 
      regulation process of POPs toxicology in zebrafish.
FAU - Zhou, Hailong
AU  - Zhou H
AD  - Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, 
      PR China.
FAU - Wu, Huifeng
AU  - Wu H
FAU - Liao, Chunyang
AU  - Liao C
FAU - Diao, Xiaoping
AU  - Diao X
FAU - Zhen, Jiping
AU  - Zhen J
FAU - Chen, Linlin
AU  - Chen L
FAU - Xue, Qinzhao
AU  - Xue Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
RN  - 0 (Receptors, Aryl Hydrocarbon)
SB  - IM
MH  - Animals
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/analysis/*toxicity
MH  - Organic Chemicals/analysis/*toxicity
MH  - Protein Transport
MH  - Receptors, Aryl Hydrocarbon/genetics/*metabolism
MH  - Toxicology/*methods
MH  - Zebrafish/metabolism
RF  - 81
EDAT- 2010/05/29 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 10.3109/15376516.2010.485227 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2010 Jul;20(6):279-86. doi: 10.3109/15376516.2010.485227.